Djibrine Mahamat Baharadine, Ngum Ngum Lesley, Maurice Boda, Chedjou Jean Paul Kengne, Netongo Palmer Masumbe
Molecular Diagnostics Research Group, Biotechnology Center, University of Yaoundé 1, Cameroon.
Department of Microbiology, Faculty of Science, University of Yaoundé 1, Cameroon.
J Family Med Prim Care. 2024 Oct;13(10):4263-4269. doi: 10.4103/jfmpc.jfmpc_103_24. Epub 2024 Oct 18.
Dengue is one of the most serious and rapidly spreading major mosquito borne diseases in the world. Despite many acute febrile illnesses in Tchad, the burden of illness due to dengue in the country is largely unknown. Hence, the present study aimed to determine the seroprevalence of dengue viral (DENV) infection and its association with hematological parameters.
A cross sectional study was carried out in Bongor Provincial Hospital. Blood samples were collected from each participant and were used to determine the hematological profile and to diagnose the presence of DENV infection. A total of 130 participants were enrolled in the study. Among these, 114 (87.7%) were diagnosed positive for DENV infection.
The majority of the positive cases were of the age group 21 to 40 years old. Leukocytosis was the most common hematological parameter affecting 120 (92.3%) of them followed by anemia and thrombocytopenia affecting 69 (53.1%) and 16 (12.3%) of them, respectively, and then lymphocytosis affecting 5 (3.8%) of them. No case of leukopenia was recorded.
The seroprevalence rate among participants suggests that the dengue virus is in circulation in Mayo Kebbi province: south of Tchad. The abnormal hematological parameters may contribute to the severity of the infection like the incidence of bleeding in the case of thrombocytopenia.
登革热是世界上最严重且传播迅速的主要蚊媒疾病之一。尽管乍得存在许多急性发热性疾病，但该国登革热所致疾病负担在很大程度上尚不明确。因此，本研究旨在确定登革热病毒（DENV）感染的血清流行率及其与血液学参数的关联。
在邦戈尔省医院开展了一项横断面研究。从每位参与者采集血样，用于确定血液学特征并诊断DENV感染的存在。共有130名参与者纳入本研究。其中，114人（87.7%）被诊断为DENV感染阳性。
大多数阳性病例为21至40岁年龄组。白细胞增多是最常见的血液学参数，120人（92.3%）受其影响，其次是贫血和血小板减少，分别有69人（53.1%）和16人（12.3%）受其影响，然后是淋巴细胞增多，有5人（3.8%）受其影响。未记录到白细胞减少病例。
参与者中的血清流行率表明登革热病毒在乍得南部的梅奥凯比省流行。血液学参数异常可能导致感染的严重程度增加，如血小板减少时出血的发生率。
