Keshavarzian A, Iber F L
Am J Gastroenterol. 1986 Apr;81(4):257-60.
Intestinal transit was assessed in 25 insulin-requiring male diabetics and 15 healthy controls by measuring the breath hydrogen appearance time after the ingestion of both the liquid and the solid meal containing nonabsorbable carbohydrate. Three groups of patients were studied: nine patients without peripheral or autonomic neuropathy or retinopathy; nine patients with peripheral neuropathy; and seven patients with peripheral and autonomic neuropathy. Eight patients complained of gastrointestinal symptoms, including three with watery diarrhea. Intestinal transit of the solid meal was more prolonged than the liquid meal in normal and diabetic subjects. There was no significant difference in intestinal transit between normal controls and any group of diabetics; however, one-third of the diabetics had abnormal intestinal transit of the liquid test meal (four rapid, four delayed); only one patient with diarrhea had rapid intestinal transit. These data suggest that abnormal intestinal transit is common in diabetics. Altered intestinal transit is not a prerequisite of diabetic diarrhea.
通过测量摄入含不可吸收碳水化合物的流食和固体食物后呼出氢气的出现时间，对25名需要胰岛素治疗的男性糖尿病患者和15名健康对照者的肠道转运情况进行了评估。研究了三组患者：9名无周围神经病变、自主神经病变或视网膜病变的患者；9名有周围神经病变的患者；7名有周围神经病变和自主神经病变的患者。8名患者主诉有胃肠道症状，其中3名有水样腹泻。在正常人和糖尿病患者中，固体食物的肠道转运时间比流食更长。正常对照组与任何一组糖尿病患者的肠道转运情况均无显著差异；然而，三分之一的糖尿病患者流食试验餐的肠道转运异常（4例快速，4例延迟）；只有1例腹泻患者肠道转运快速。这些数据表明，肠道转运异常在糖尿病患者中很常见。肠道转运改变并非糖尿病腹泻的必要条件。
