Sarno S, Erasmas L P, Haslbeck M, Hölzl R
Klinische Psychologie, Universität Mannheim, III Medizinische Abteilung, Krankenhaus München Schwabing, Germany.
Ital J Gastroenterol. 1993 Nov-Dec;25(9):490-6.
Orocaecal transit time was investigated using the hydrogen breath test in 39 insulin-requiring patients with long-standing Type I diabetes mellitus and 26 healthy control subjects. Thirty four patients complained of different gastrointestinal symptoms. The standard meal consisted of 10 g lactulose in 150 ml tap water. Mean transit time was significantly longer in the patient group (106.4 +/- 31.1 min) than in control subjects (84.2 +/- 27.1 min), and differences in OCTT between symptomatic subgroups were also significant. No correlation was found between orocaecal transit time and gastric emptying of a solid meal measured with scintigraphic method, HbA1c values, and other signs of automatic and peripheral neuropathy. The incidence of bacterial overgrowth among the diabetics was minimal. The percentage of H2 non-producers did not significantly differ between control and patient groups (23% and 26%, respectively). The absolute amount of breathed hydrogen was, however, significantly lower in diabetics at all time intervals. This indicates that specific changes in hydrogen production may be related to pathophysiological features as a consequence or as an associated symptom.
采用氢呼气试验对39例需要胰岛素治疗的长期1型糖尿病患者和26名健康对照者的口盲肠转运时间进行了研究。34例患者有不同的胃肠道症状。标准餐为150毫升自来水中含10克乳果糖。患者组的平均转运时间（106.4±31.1分钟）显著长于对照组（84.2±27.1分钟），有症状亚组之间的口盲肠转运时间差异也很显著。口盲肠转运时间与用闪烁扫描法测量的固体餐胃排空、糖化血红蛋白值以及自主神经和周围神经病变的其他体征之间未发现相关性。糖尿病患者中细菌过度生长的发生率极低。对照组和患者组中不产生氢气者的百分比无显著差异（分别为23%和26%）。然而，在所有时间间隔，糖尿病患者呼出氢气的绝对量均显著较低。这表明氢气产生的特定变化可能与病理生理特征有关，是其结果或相关症状。
