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Lancet Child Adolesc Health. 2022 Jun;6(6):432-444. doi: 10.1016/S2352-4642(22)00067-0. Epub 2022 Apr 11.
3
Prevalence estimation of intellectual disability using national administrative and household survey data: The importance of survey question specificity.使用国家行政和家庭调查数据估计智力残疾的流行率:调查问题特异性的重要性。
Int J Popul Data Sci. 2021 Jan 28;6(1):1342. doi: 10.23889/ijpds.v6i1.1342.
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Age at onset of mental disorders worldwide: large-scale meta-analysis of 192 epidemiological studies.全球精神障碍发病年龄:192 项流行病学研究的大规模荟萃分析。
Mol Psychiatry. 2022 Jan;27(1):281-295. doi: 10.1038/s41380-021-01161-7. Epub 2021 Jun 2.
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The World Federation of ADHD International Consensus Statement: 208 Evidence-based conclusions about the disorder.世界注意缺陷多动障碍(ADHD)国际联合会共识声明:208 条关于该障碍的循证结论。
Neurosci Biobehav Rev. 2021 Sep;128:789-818. doi: 10.1016/j.neubiorev.2021.01.022. Epub 2021 Feb 4.
6
Patterns of comorbidity and psychopharmacology in adults with intellectual disability and attention deficit hyperactivity disorder: an UK national cross-sectional audit.智力残疾和注意缺陷多动障碍成人共病模式和精神药理学:英国全国横断面审计。
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Autism. 2020 May;24(4):1011-1024. doi: 10.1177/1362361320908972. Epub 2020 Mar 19.
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Sociol Health Illn. 2020 Feb;42(2):262-276. doi: 10.1111/1467-9566.13001. Epub 2019 Sep 27.

智力残疾患者儿童期风险因素及成年期临床与服务结局

Childhood risk factors and clinical and service outcomes in adulthood in people with intellectual disabilities.

作者信息

Perera B, Mufti S, Norris C, Baksh A, Totsika V, Hassiotis A, Hurks P, van Amelsvoort T

机构信息

Division of Psychiatry, University College London, UK.

Hanringey LD Services, Barnet, Enfield and Haringey MH Trust, London, UK.

出版信息

BJPsych Open. 2024 Dec 4;10(6):e218. doi: 10.1192/bjo.2024.811.

DOI:10.1192/bjo.2024.811
PMID:39629613
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11698209/
Abstract

BACKGROUND

Adults with intellectual disability experience increased rates of mental health disorders and adverse mental health outcomes.

AIM

Explore childhood risk factors associated with adverse mental health outcomes during adulthood as defined by high cost of care, use of psychotropic medication without a severe mental illness and psychiatric hospital admissions.

METHOD

Data on 137 adults with intellectual disability were collected through an intellectual disability community service in an inner London borough. Childhood modifiable and non-modifiable risk factors were extracted from records to map onto variables identified as potential risk factors. Logistic and linear regression models were employed to analyse their associations with adverse outcomes.

RESULTS

We showed that the co-occurrence of intellectual disability with autism spectrum disorder and/or attention-deficit hyperactivity disorder (ADHD) were associated with psychotropic medication use and high-cost care packages. However, when challenging behaviour during childhood was added, ADHD and autism spectrum disorder were no longer significant and challenging behaviour better explained medication prescribing and higher cost care. In addition, the severity of intellectual disability was associated with higher cost care packages. Ethnicity (Black and mixed) also predicted higher cost of care.

CONCLUSIONS

Challenging behaviour during childhood emerged as a critical variable affecting outcomes in young adulthood and mediated the association between adult adverse mental health outcomes and co-occurring neurodevelopmental conditions, that is, ADHD and autism. These findings emphasise the need for effective early intervention strategies to address challenging behaviour during childhood. Such interventions for challenging behaviour will need to take into consideration autism and ADHD.

摘要

背景

成年智障人士心理健康障碍及不良心理健康结局的发生率较高。

目的

探讨与成年期不良心理健康结局相关的童年风险因素,这些不良结局定义为护理成本高、在无严重精神疾病情况下使用精神药物以及入住精神病医院。

方法

通过伦敦市中心一个行政区的智障社区服务机构收集了137名成年智障人士的数据。从记录中提取童年期可改变和不可改变的风险因素,以对应确定为潜在风险因素的变量。采用逻辑回归和线性回归模型分析它们与不良结局的关联。

结果

我们发现,智障与自闭症谱系障碍和/或注意力缺陷多动障碍(ADHD)同时存在与使用精神药物和高成本护理套餐有关。然而,当加入童年期的挑战行为时,ADHD和自闭症谱系障碍不再具有显著性,挑战行为能更好地解释药物处方和更高成本的护理。此外,智障的严重程度与更高成本的护理套餐有关。种族(黑人及混血)也预示着更高的护理成本。

结论

童年期的挑战行为成为影响青年期结局的关键变量,并介导了成年期不良心理健康结局与同时存在的神经发育状况(即ADHD和自闭症)之间的关联。这些发现强调了需要有效的早期干预策略来解决童年期的挑战行为。针对挑战行为的此类干预措施需要考虑自闭症和ADHD。