使用伽马振荡的适应性深部脑刺激对帕金森病的持续临床益处：一例报告
Sustained Clinical Benefit of Adaptive Deep Brain Stimulation in Parkinson's Disease Using Gamma Oscillations: A Case Report.
作者信息
Cernera Stephanie, Oehrn Carina R, Hammer Lauren H, Shcherbakova Maria, Yao Jiaang, Hahn Amelia, Wang Sarah, Ostrem Jill L, Little Simon, Starr Philip A
机构信息
Department of Neurological Surgery, University of California, San Francisco, California, USA.
Department of Neurology, University of California, San Francisco, California, USA.
出版信息
Mov Disord. 2025 Feb;40(2):345-350. doi: 10.1002/mds.30076. Epub 2024 Dec 4.
BACKGROUND
Adaptive deep brain stimulation (aDBS) dynamically adjusts stimulation parameters according to patient needs. We recently showed that chronic aDBS utilizing invasive neural signals for feedback control is superior to conventional DBS (cDBS) during normal daily life in a 2-month trial. The stability of aDBS over longer periods remains unclear.
OBJECTIVES
To assess the effects of aDBS on motor symptoms and quality of life (QoL) in one individual with Parkinson's disease over 8 months.
METHODS
We used stimulation-entrained cortical gamma oscillations as a control signal for aDBS in the subthalamic nucleus and quantified benefits using motor diary ratings, QoL scales, and wearable metrics.
RESULTS
We found that aDBS delivered superior and consistent benefits compared with baseline cDBS in measures of bradykinesia and QoL.
CONCLUSIONS
aDBS can achieve prolonged, stable improvement over clinically optimized cDBS. The neural signal remains stable, and aDBS parameters remain appropriate over extended periods. © 2024 International Parkinson and Movement Disorder Society.
背景
适应性深部脑刺激（aDBS）可根据患者需求动态调整刺激参数。我们最近在一项为期2个月的试验中表明，在正常日常生活中，利用侵入性神经信号进行反馈控制的慢性aDBS优于传统深部脑刺激（cDBS）。aDBS在更长时期内的稳定性仍不清楚。
目的
评估aDBS对一名帕金森病患者8个月内运动症状和生活质量（QoL）的影响。
方法
我们将刺激诱发的皮质γ振荡用作丘脑底核aDBS的控制信号，并使用运动日记评分、生活质量量表和可穿戴指标来量化益处。
结果
我们发现，在运动迟缓测量和生活质量方面，与基线cDBS相比，aDBS带来了更显著且持续的益处。
结论
与临床优化的cDBS相比，aDBS可实现长期、稳定的改善。神经信号保持稳定，aDBS参数在较长时间内保持适宜。© 2024国际帕金森和运动障碍协会。
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