Albaneze Natasha, Cotton Cary C, Anderson Chelsea, Katzka David A, Dellon Evan S
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Aliment Pharmacol Ther. 2025 Jan;61(2):363-368. doi: 10.1111/apt.18431. Epub 2024 Dec 4.
While inflammation is implicated in the development of numerous cancers, whether eosinophilic oesophagitis (EoE) increases the risk of oesophageal cancer (OCa) remains understudied.
To assess whether adults with EoE were more likely to have subsequent OCa diagnosis.
This case-control study used data from the MarketScan commercial claims database. Cases were 18-64 years old with an oesophageal cancer diagnosis (≥ two coding instances) who had no previous oesophageal cancer code. Controls were matched 10:1 by age and time in health plan. All cases and controls had at least 2 years of continuous healthcare coverage before the index date. EoE status required ≥ two coding instances. We used conditional logistic regression modelling to assess the association between EoE and oesophageal cancer.
Of 5562 eligible cases and 55,620 matched controls, median age was 58.8 years and median number of years in health plan was 5.1. The proportions of male cases and controls were 81.3% and 41.4%, respectively. A history of EoE was rare in both cases and controls. Only two oesophageal cancer cases (0.04%) and 44 controls (0.08%) had evidence of an EoE diagnosis (OR 0.46; 95% CI 0.11-1.88).
EoE is not associated with the development of oesophageal cancer in privately insured adults under 65 years old; co-incidence of EoE and oesophageal cancer is extremely rare. Additional studies are needed to confirm these findings and to evaluate whether they hold in older adults or over longer follow-up, and whether EoE might protect against oesophageal cancer.
虽然炎症与多种癌症的发生有关，但嗜酸性粒细胞性食管炎（EoE）是否会增加食管癌（OCa）的风险仍未得到充分研究。
评估患有EoE的成年人是否更有可能随后被诊断为OCa。
这项病例对照研究使用了MarketScan商业索赔数据库中的数据。病例为18 - 64岁，有食管癌诊断（≥两个编码实例）且既往无食管癌编码。对照组按年龄和在健康计划中的时间以10:1进行匹配。所有病例和对照在索引日期前至少有2年的连续医保覆盖。EoE状态需要≥两个编码实例。我们使用条件逻辑回归模型来评估EoE与食管癌之间的关联。
在5562例符合条件的病例和55620例匹配的对照中，中位年龄为58.8岁，在健康计划中的中位年数为5.1年。病例组和对照组中男性的比例分别为81.3%和41.4%。EoE病史在病例组和对照组中都很罕见。只有2例食管癌病例（0.04%）和44例对照（0.08%）有EoE诊断的证据（比值比0.46；95%置信区间0.11 - 1.88）。
在65岁以下有私人保险的成年人中，EoE与食管癌的发生无关；EoE和食管癌的同时发生极为罕见。需要进一步的研究来证实这些发现，并评估它们在老年人中是否成立或在更长的随访期内是否成立，以及EoE是否可能预防食管癌。
