氟比洛芬治疗强直性脊柱炎。与吲哚美辛的比较。

Flurbiprofen in the treatment of ankylosing spondylitis. A comparison with indomethacin.

作者信息

Lomen P L, Turner L F, Lamborn K R, Brinn E L

出版信息

Am J Med. 1986 Mar 24;80(3A):127-32. doi: 10.1016/0002-9343(86)90129-4.

Abstract

In this randomized, double-blind study, 57 patients with ankylosing spondylitis were evaluated after 26 weeks of treatment with either flurbiprofen (Ansaid, Upjohn) or indomethacin. Flurbiprofen administered four times a day in a total daily dose of 200 mg was effective in controlling the pain and associated symptoms of ankylosing spondylitis. Pain was adequately controlled in some patients following a total daily dose of 100 mg of flurbiprofen administered twice a day. Flurbiprofen was as effective as indomethacin in most key efficacy measurements analyzed. The drug was well tolerated in doses of up to 300 mg per day, and no clinically significant laboratory abnormalities were detected. Flurbiprofen is an excellent treatment for the control of pain and inflammation in patients with ankylosing spondylitis.

摘要

在这项随机双盲研究中，57例强直性脊柱炎患者在接受氟比洛芬（安赛蜜，优普强公司生产）或吲哚美辛治疗26周后接受评估。每日分四次服用氟比洛芬，每日总剂量为200毫克，可有效控制强直性脊柱炎的疼痛及相关症状。部分患者每日两次服用总量100毫克的氟比洛芬后，疼痛得到充分控制。在分析的大多数关键疗效指标中，氟比洛芬与吲哚美辛效果相当。该药物每日剂量高达300毫克时耐受性良好，未检测到具有临床意义的实验室异常。氟比洛芬是控制强直性脊柱炎患者疼痛和炎症的一种优秀治疗药物。