Varone Bruno Butturi, Leal Daniel Peixoto, Perini Daniel Duarte, Pagotto Vitor Penteado Figueiredo, Gobbi Riccardo Gomes, Demange Marco Kawwamura
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP), São Paulo, SP, Brazil.
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP), São Paulo, SP, Brazil.
Clinics (Sao Paulo). 2024 Dec 3;80:100527. doi: 10.1016/j.clinsp.2024.100527. eCollection 2025.
Knee osteoarthritis is a debilitating disease that has been increasing in prevalence, especially due to the aging population and rising incidence of obesity. Biological therapies (orthobiologics) have emerged, demonstrating efficacy in improving functional scores, including the injection of microfragmented Adipose Tissue (mFAT). The purpose of this study is to evaluate the safety of adipose tissue harvesting and mFAT injection under local anesthesia.
MATERIALS/METHODS: A case series involving 34 patients who underwent adipose tissue collection from the abdomen under local anesthesia, without sedation, in a sterile environment, and who received the infiltration of microfragmented adipose tissue after single-time preparation, using a fat washing and microfragmentation kit.
Evaluation was performed at the time of the procedure and after 7 days of follow-up. Only ecchymosis (76.5 %) and mild discomfort at the harvested site (70.6 %), as well as mild discomfort at the infiltrated knee (61.8 %), were identified. No major adverse events were identified.
The harvesting and injection of mFAT under local anesthesia is safe, with no major adverse events identified during this procedure.
膝关节骨关节炎是一种使人衰弱的疾病，其患病率一直在上升，尤其是由于人口老龄化和肥胖症发病率的上升。生物疗法（orthobiologics）已经出现，在改善功能评分方面显示出疗效，包括注射微片段化脂肪组织（mFAT）。本研究的目的是评估在局部麻醉下采集脂肪组织和注射mFAT的安全性。
材料/方法：这是一个病例系列，涉及34例患者，他们在无菌环境中于局部麻醉下（未使用镇静剂）从腹部采集脂肪组织，并在单次制备后使用脂肪清洗和微片段化试剂盒接受微片段化脂肪组织的浸润注射。
在手术时和随访7天后进行评估。仅发现有瘀斑（76.5%）、采集部位轻度不适（70.6%）以及浸润膝关节轻度不适（61.8%）。未发现重大不良事件。
在局部麻醉下采集和注射mFAT是安全的，在此过程中未发现重大不良事件。
