线粒体呼吸超复合物助力棕色脂肪组织产热。
Mitochondrial respiratory supercomplexes gear up for heat generation in brown adipose tissue.
作者信息
Carlström Andreas, Ott Martin
机构信息
Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, 405 30 Gothenburg, Sweden.
Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, 405 30 Gothenburg, Sweden.
出版信息
Cell Metab. 2024 Dec 3;36(12):2491-2492. doi: 10.1016/j.cmet.2024.10.022.
Mitochondrial energy conversion supplies cellular energy but can also provide heat in brown adipose tissue (BAT). In a recent study, Shin and Latorre-Muro et al. show that respiratory supercomplexes in BAT are remodeled during cold to provide a tighter coupling, revealing a novel, physiologically important role for these supramolecular assemblies.
线粒体能量转换为细胞提供能量，但在棕色脂肪组织（BAT）中也能产生热量。在最近的一项研究中，Shin和Latorre-Muro等人表明，棕色脂肪组织中的呼吸超复合物在寒冷时会发生重塑，以实现更紧密的偶联，揭示了这些超分子组装体在生理上的一个新的重要作用。
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