Seddio Anthony E, Jabbouri Sahir S, Gouzoulis Michael J, Vasudevan Rajiv S, Halperin Scott J, Varthi Arya G, Rubio Daniel R, Grauer Jonathan N
Department of Orthopaedics & Rehabilitation, Yale School of Medicine, 47 College St, New Haven, CT, USA.
Department of Orthopaedics & Rehabilitation, Yale School of Medicine, 47 College St, New Haven, CT, USA.
Spine J. 2025 May;25(5):911-920. doi: 10.1016/j.spinee.2024.11.018. Epub 2024 Dec 2.
Patients undergoing anterior cervical discectomy and fusion (ACDF) often have brief inpatient stays and may be at risk for inpatient falls (IPFs). Such IPFs should be preventable and have been termed a "never event" by the National Quality Forum, an affiliate of The Joint Commission. Despite increasing attention to IPF prevention, no studies have investigated the incidence, trends, and factors associated with IPFs among ACDF patients.
To characterize the trends in the incidence of ACDF-related IPFs and their risk factors.
STUDY DESIGN/SETTING: Retrospective cohort study.
Adult patients who underwent inpatient ACDF between 2010 and Q3 2022 were abstracted from a large, national, multiinsurance administrative claims database.
Incidence, trends, and factors associated with IPFs.
Adult patients who had undergone single or multilevel inpatient ACDF were identified by administrative coding. Exclusion criteria included: patients <18 years of age, those who underwent outpatient ACDF, concurrent posterior cervical procedures, thoracic or lumbar fusion, and those with trauma, neoplasm, or infection diagnosed within 90-days prior to surgery. The subset of patients who suffered an IPF were subsequently identified. The annual incidence of IPFs was analyzed over the study years and various risk factors were assessed for their correlation with IPFs by multivariable logistic regression. To determine the association between IPF and length of stay (LOS), patients with relative to without IPF were matched 1:4 based on age, sex, and Elixhauser Comorbidity Index (ECI) and compared by multivariable logistic regression.
Of the 294,165 inpatient ACDF patients meeting inclusion criteria, IPFs were identified for 5,548 (1.9%). Between 2010 and Q3 2022, the annual incidence of IPFs increased from 309 (1.1%) to 515 (4.8%) for patients undergoing ACDF (p<.001). Independent predictors of an IPF were: hospital-acquired delirium (odds ratio [OR] 4.50), history of prior falls (OR 3.38), hospital-acquired psychosis (OR 3.17), alcohol use disorder (OR 2.68), cervical myelopathy (relative to radiculopathy) (OR 2.66), socioeconomically disadvantaged patients (OR 1.85), history of dementia (OR 1.77), underweight body mass index (BMI <18.5) (OR 1.67), multilevel ACDF (OR 1.43), history of prior cervical surgery (OR 1.41), male sex (OR 1.37), Medicaid insurance (OR 1.34), older age (OR 1.33), patients in the northeast United States (OR 1.15), and obese BMI >30 (OR 1.15) (p<.001 for all). Relative to patients without IPF, patients who suffered an IPF following ACDF demonstrated incrementally increasing odds of extended LOS (4-5 days [OR 2.63], 6 to 7 days [OR 3.85], 7+ days [OR 6.78]) (p<.001 for all).
In this robust national sample of patients undergoing inpatient ACDF, IPFs were identified for 1.9%, with an increasing annual incidence over the years. Among these patients, various factors were associated with their occurrence, many of which may be potentially modifiable. These findings have major clinical implications on care pathway optimization regarding early identification of high-risk patients undergoing ACDF and lays a foundation for the refinement of multidisciplinary fall prevention programs.
接受颈椎前路椎间盘切除融合术(ACDF)的患者住院时间通常较短,可能存在住院跌倒(IPF)风险。此类住院跌倒应是可预防的,美国国家质量论坛(联合委员会的附属机构)将其称为“绝不允许发生的事件”。尽管对预防住院跌倒的关注度不断提高,但尚无研究调查ACDF患者中住院跌倒的发生率、趋势及相关因素。
描述ACDF相关住院跌倒的发生率趋势及其危险因素。
研究设计/地点:回顾性队列研究。
从一个大型的全国性多保险行政索赔数据库中提取2010年至2022年第三季度期间接受住院ACDF的成年患者。
与住院跌倒相关的发生率、趋势和因素。
通过行政编码识别接受单节段或多节段住院ACDF的成年患者。排除标准包括:年龄<18岁的患者、接受门诊ACDF的患者、同期颈椎后路手术患者、胸椎或腰椎融合手术患者,以及术前90天内诊断为创伤、肿瘤或感染的患者。随后确定发生住院跌倒的患者子集。分析研究期间住院跌倒的年发生率,并通过多变量逻辑回归评估各种危险因素与住院跌倒的相关性。为确定住院跌倒与住院时间(LOS)之间的关联,根据年龄、性别和埃利克斯豪泽合并症指数(ECI),将有住院跌倒与无住院跌倒的患者按1:4进行匹配,并通过多变量逻辑回归进行比较。
在符合纳入标准的294,165例住院ACDF患者中,有5548例(1.9%)发生了住院跌倒。在2010年至2022年第三季度期间,接受ACDF的患者住院跌倒的年发生率从309例(1.1%)增至515例(4.8%)(p<0.001)。住院跌倒的独立预测因素包括:医院获得性谵妄(比值比[OR]4.50)、既往跌倒史(OR 3.38)、医院获得性精神病(OR 3.17)、酒精使用障碍(OR 2.68)、脊髓型颈椎病(相对于神经根型颈椎病)(OR 2.66)、社会经济地位不利的患者(OR 1.85)、痴呆病史(OR 1.77)体重过轻(体重指数<18.5)(OR 1.67)、多节段ACDF(OR 1.43)、既往颈椎手术史(OR 1.41)、男性(OR 1.37)、医疗补助保险(OR 1.34)、年龄较大(OR 1.33)、美国东北部的患者(OR 1.15)以及肥胖(体重指数>30)(OR 1.15)(所有p<0.001)。与无住院跌倒的患者相比,ACDF后发生住院跌倒的患者住院时间延长的几率逐渐增加(4 - 5天[OR 2.63],6至7天[OR 3.85],7天以上[OR 6.78])(所有p<0.001)。
在这个强大的全国性住院ACDF患者样本中,住院跌倒发生率为1.9%,且多年来年发生率呈上升趋势。在这些患者中,多种因素与其发生相关,其中许多因素可能是潜在可改变的。这些发现对优化护理路径以早期识别接受ACDF的高危患者具有重要临床意义,并为完善多学科跌倒预防计划奠定了基础。