Zhang Li, Wei Ziqing, Dai Yuwan, He Fucheng, Sun Ting
Key Clinical Laboratory of Henan Province, Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China; Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450052, Henan, China.
Neuropharmacology. 2025 Mar 1;265:110247. doi: 10.1016/j.neuropharm.2024.110247. Epub 2024 Dec 3.
Neurotransmitter and neuromodulator release by Ca-regulated exocytosis is essential for information transmisson between cells. Formation of SNARE complex (soluble N-ethylmaleimide sensitive factor attachment protein receptors) provide energy to bring vesicles and the plasma membranes together and catalyze membrane fusion. The "Ca-dependent activator protein for secretion" (CAPS) assumes a pivotal role in facilitating vesicle content release, not only in the nervous system but also in various other secretory tissues. In recent years, great progress has been made in the study of the mechanism of CAPS regulating vesicle secretion. In this review, we summarize recent advances toward the functions and molecular mechanisms of CAPSs in vesicle exocytosis, and contemplate future research directions that will illuminate the molecular mechanisms of neurodegeneration.
通过钙调节的胞吐作用释放神经递质和神经调质对于细胞间的信息传递至关重要。SNARE复合体（可溶性N-乙基马来酰亚胺敏感因子附着蛋白受体）的形成提供能量，使囊泡与质膜结合在一起并催化膜融合。“分泌的钙依赖性激活蛋白”（CAPS）在促进囊泡内容物释放方面发挥着关键作用，不仅在神经系统中如此，在其他各种分泌组织中也是如此。近年来，在CAPS调节囊泡分泌机制的研究方面取得了很大进展。在这篇综述中，我们总结了CAPS在囊泡胞吐作用中的功能和分子机制的最新进展，并思考未来的研究方向，这些方向将阐明神经退行性变的分子机制。
