Morioka Yui, Ano Naoko, Tatsuno Yuko, Nomura Kohji, Ozaki Kiyokazu
MLT Co., Ltd., Osaka, Japan.
Yamada Animal Hospital, Fukui, Japan.
J Vet Med Sci. 2025 Jan 1;87(1):57-60. doi: 10.1292/jvms.24-0345. Epub 2024 Dec 4.
An ocular mass was noted in the right iridociliary region of a 13-year-old male beagle dog. The right eyeball was surgically removed. Histopathologically, the mass was located mainly in the ciliary body and appeared to be continuous with non-pigmented epithelial cells. The polygonal neoplastic cells proliferated in sheets with periodic acid-Schiff-positive basement membrane material. Neoplastic cells had small round nuclei with no atypia or mitosis, and abundant, pale eosinophilic, granular, and rarified cytoplasm displayed ballooning change. No invasive growth or metastasis was observed. Immunohistochemically, the cells were positive for vimentin, neuron-specific enolase, and S100, and negative for cytokeratin AE1/AE3, Iba-1, CD204, MelanA, Sox10, and PNL2. Based on these findings, the lesion was diagnosed as an iridociliary adenoma with ballooning change.
在一只13岁雄性比格犬的右眼虹膜睫状体区域发现一个眼部肿物。右眼眼球被手术摘除。组织病理学检查显示，肿物主要位于睫状体，似乎与无色素上皮细胞相连。多边形肿瘤细胞呈片状增殖，伴有过碘酸希夫阳性的基底膜物质。肿瘤细胞有小而圆的核，无异型性或有丝分裂，且胞质丰富、淡嗜酸性、颗粒状且稀薄，呈现气球样变。未观察到浸润性生长或转移。免疫组织化学检查显示，细胞波形蛋白、神经元特异性烯醇化酶和S100呈阳性，细胞角蛋白AE1/AE3、离子钙结合衔接分子1、CD204、黑素A、Sox10和PNL2呈阴性。基于这些发现，该病变被诊断为伴有气球样变的虹膜睫状体腺瘤。
