Kushida Kazuya, Matsumoto Miu, Tamazawa Mizuki, Yamazaki Kentaro, Shimizu Eisei, Kaneyama Airi, Yoshimura Aritada, Miyahara Shunsuke, Tashiro Kodai, Lee Kija, Katayama Masaaki, Fukushima Ryuji, Kishimoto Miori
Cooperative Division of Veterinary Sciences, Tokyo University of Agriculture and Technology, 3-8-1 Harumi-cho, Fuchu, Tokyo 183-8538, Japan.
Koganei Animal Medical Emergency Center, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan.
Exp Anim. 2025 Apr 20;74(2):209-215. doi: 10.1538/expanim.24-0134. Epub 2024 Dec 5.
This study aimed to determine the feasibility of using perfusion computed tomography (CT) to assess blood flow in different regions of the stomach in dogs. Dynamic perfusion CT scans were conducted on five beagle dogs, and blood flow analysis was performed using the maximum slope and Patlak plot methods. The findings revealed significant variations in blood flow among the fundus, body, and pylorus of the stomach. Specifically, the body showed approximately 1.3 times higher blood flow than the fundus and approximately 5 times higher blood flow than the pylorus. There were no significant differences in blood flow between the two analysis algorithms. The findings suggest that gastric perfusion CT can accurately detect variations in blood flow within the stomach. Using the maximum slope method for analysis allows for noninvasive and rapid measurement of gastric blood flow. This technique may have clinical applications in detecting submucosal diseases that are challenging to identify with endoscopies and serve as a valuable noninvasive tool for longitudinal observations in experimental animal studies.
本研究旨在确定使用灌注计算机断层扫描（CT）评估犬胃不同区域血流的可行性。对5只比格犬进行了动态灌注CT扫描，并使用最大斜率法和Patlak图法进行血流分析。结果显示，胃底、胃体和幽门的血流存在显著差异。具体而言，胃体的血流比胃底高约1.3倍，比幽门高约5倍。两种分析算法之间的血流无显著差异。研究结果表明，胃灌注CT能够准确检测胃内血流变化。使用最大斜率法进行分析可实现对胃血流的无创快速测量。该技术可能在检测内镜检查难以识别的黏膜下疾病方面具有临床应用价值，并可作为实验动物研究纵向观察的一种有价值的无创工具。
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