An Soyon, Hwang Gunha, Noh Seul Ah, Lee Hee Chun, Hwang Tae Sung
Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea.
AniCom Medical Center, Animal Hospital, Seoul 04599, Republic of Korea.
Vet Sci. 2023 Jul 18;10(7):469. doi: 10.3390/vetsci10070469.
Brain computed tomography (CT) perfusion is a technique that allows for the fast evaluation of cerebral hemodynamics. However, quantitative studies of brain CT perfusion in veterinary medicine are lacking. The purpose of this study was to investigate the normal range of perfusion determined via CT in brains of healthy dogs and to compare values between white matter and gray matter, differences in aging, and each hemisphere. Nine intact male beagle dogs were prospectively examined using dynamic CT scanning and post-processing for brain perfusion. Regional cerebral blood volume (rCBV), regional cerebral blood flow (rCBF), mean transit time, and time to peak were calculated. Tissue ROIs were drawn in the gray matter and white matter of the frontal, temporal, parietal, and occipital lobes; caudate nucleus; thalamus; piriform lobe; hippocampus; and cerebellum. Significant differences were observed between the white matter regions and gray matter regions for rCBV and rCBF ( < 0.05). However, no significant differences were identified between hemispheres and between young and old groups in brain regions. The findings obtained in this study involving healthy beagle dogs might serve as a reference for regional CT perfusion values in specific brain regions. These results may aid in the characterization of various brain diseases in dogs.
脑计算机断层扫描（CT）灌注是一种能够快速评估脑血流动力学的技术。然而，兽医学中关于脑CT灌注的定量研究尚属空白。本研究的目的是通过CT测定健康犬脑的正常灌注范围，并比较白质和灰质之间的数值、年龄差异以及各脑半球之间的差异。对9只健康雄性比格犬进行前瞻性研究，采用动态CT扫描及脑灌注后处理技术。计算局部脑血容量（rCBV）、局部脑血流量（rCBF）、平均通过时间和达峰时间。在额叶、颞叶、顶叶和枕叶的灰质和白质、尾状核、丘脑、梨状叶、海马和小脑中绘制组织感兴趣区（ROI）。rCBV和rCBF在白质区域和灰质区域之间存在显著差异（<0.05）。然而，在脑区的半球之间以及年轻组和老年组之间未发现显著差异。本研究中涉及健康比格犬的结果可能为特定脑区的CT灌注值提供参考。这些结果可能有助于犬类各种脑部疾病的特征描述。
