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在一项针对酒精性肝硬化患者的多中心研究中,与酒精使用障碍治疗利用情况相关的人口统计学和临床特征。

Demographic and clinical characteristics associated with utilization of alcohol use disorder treatment in a multicenter study of patients with alcohol-associated cirrhosis.

作者信息

Luk Jeremy W, Ha Nghiem B, Shui Amy M, Snyder Hannah R, Batki Steven L, Ostacher Michael J, Monto Alexander, Wong Robert J, Cheung Ramsey, Parekh Priti, Hua William, Tompkins D Andrew, Fakadej Taylor, Haight Christina G, Liao Meimei, Khalili Mandana, Satre Derek D

机构信息

Office of the Clinical Director, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA.

Division of Gastroenterology and Hepatology, Department of Medicine, University of California, San Francisco, California, USA.

出版信息

Alcohol Clin Exp Res (Hoboken). 2025 Jan;49(1):244-255. doi: 10.1111/acer.15500. Epub 2024 Dec 4.

Abstract

BACKGROUND

Alcohol use disorder (AUD) treatment can help improve clinical outcomes among patients with alcohol-associated cirrhosis but is underutilized. Among socioeconomically disadvantaged patients with alcohol-associated cirrhosis, we examined rates of lifetime and past 12-month AUD treatment utilization and associated demographic and clinical characteristics.

METHODS

Racial/ethnically diverse patients with alcohol-associated cirrhosis who had at least one hepatology clinic visit in the prior 6 months were recruited from three Northern California medical centers serving veterans and safety-net populations. Participants self-reported their AUD treatment utilization, liver disease quality of life (LDQoL), history and current symptoms of anxiety and depression, and problematic drinking as measured by the Alcohol Use Disorders Identification Test (AUDIT). Clinical measures including liver disease severity were captured from medical records.

RESULTS

Among 196 participants, the majority were male (88%) with a mean age of 62 years. Two-thirds of participants (67%) reported ever utilizing AUD treatment and 32% reported utilizing AUD treatment in the past 12 months. Compared with those who did not utilize AUD treatment, participants who utilized lifetime or past 12-month AUD treatment were younger, had lower LDQoL scores, and had higher scores on current symptoms of anxiety, depression, and problematic drinking. In multivariable analyses, the odds of ever utilizing pharmacological treatment alone or both behavioral and pharmacological treatment (vs. none) were lower with older age or higher LDQoL, and higher among those with a history of anxiety/depressive disorder. For past 12-month treatment utilization, odds were lower with older age, and higher among those with current clinically significant anxiety/depression or problematic drinking.

CONCLUSIONS

Patients with alcohol-associated cirrhosis who were younger or had anxiety/depression and problematic drinking were more likely to utilize AUD treatment. To improve AUD treatment utilization, targeted outreach to patients less likely to receive care and the provision of integrated ALD and AUD treatment is warranted.

摘要

背景

酒精使用障碍(AUD)治疗有助于改善酒精相关性肝硬化患者的临床结局,但目前未得到充分利用。在社会经济地位不利的酒精相关性肝硬化患者中,我们研究了终生及过去12个月AUD治疗的利用率以及相关的人口统计学和临床特征。

方法

从北加利福尼亚州为退伍军人和安全网人群服务的三个医疗中心招募在过去6个月内至少有一次肝病门诊就诊的不同种族/族裔的酒精相关性肝硬化患者。参与者自行报告其AUD治疗利用率、肝病生活质量(LDQoL)、焦虑和抑郁的病史及当前症状,以及通过酒精使用障碍识别测试(AUDIT)测量的问题饮酒情况。从病历中获取包括肝病严重程度在内的临床指标。

结果

196名参与者中,大多数为男性(88%),平均年龄62岁。三分之二的参与者(67%)报告曾使用过AUD治疗,32%报告在过去12个月内使用过AUD治疗。与未使用AUD治疗的参与者相比,使用过终生或过去12个月AUD治疗的参与者更年轻,LDQoL得分更低,焦虑、抑郁和问题饮酒的当前症状得分更高。在多变量分析中,仅使用药物治疗或同时使用行为和药物治疗(与未治疗相比)的几率在年龄较大或LDQoL较高的患者中较低,而在有焦虑/抑郁障碍病史的患者中较高。对于过去12个月的治疗利用率,年龄较大的患者几率较低,而当前有临床显著焦虑/抑郁或问题饮酒的患者几率较高。

结论

年龄较小或有焦虑/抑郁及问题饮酒的酒精相关性肝硬化患者更有可能使用AUD治疗。为了提高AUD治疗的利用率,有必要针对不太可能接受治疗的患者进行有针对性的宣传,并提供综合的酒精性肝病和AUD治疗。

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