Paydarfar D, Eldridge F L, Kiley J P
Am J Physiol. 1986 Apr;250(4 Pt 2):R721-7. doi: 10.1152/ajpregu.1986.250.4.R721.
The purpose of this study was to use topological methods of analysis to determine if a phase singularity exists for the neural respiratory oscillator. We studied resetting behavior of central respiratory rhythm, measured as phrenic nerve activity, by using brief stimulations of the superior laryngeal nerve in anesthetized paralyzed adult cats. The strength and timing of stimuli were varied, and the times of onset of subsequent breaths were measured. Two distinct types of phase resetting were identified: type 1 resetting for weak stimuli and type 0 resetting for strong stimuli. With stimuli of intermediate strength, we obtained a series of phase-resetting curves that defined a helicoid-resetting surface having a phase singularity near the transition between late expiration and early inspiration. In this domain resumption of breathing occurred at highly variable resetting times. The mammalian respiratory oscillator thus has qualitative characteristics of response to brief stimuli that are similar to those of other biological oscillators.
本研究的目的是运用拓扑分析方法来确定神经呼吸振荡器是否存在相位奇点。我们通过对麻醉瘫痪的成年猫的喉上神经进行短暂刺激，研究了以膈神经活动为指标的中枢呼吸节律的重置行为。改变刺激的强度和时间，并测量随后呼吸开始的时间。确定了两种不同类型的相位重置：弱刺激时的1型重置和强刺激时的0型重置。对于中等强度的刺激，我们获得了一系列相位重置曲线，这些曲线定义了一个螺旋面重置表面，在呼气末期和吸气早期之间的过渡附近存在一个相位奇点。在这个区域，呼吸恢复发生在高度可变的重置时间。因此，哺乳动物呼吸振荡器对短暂刺激的反应具有与其他生物振荡器相似的定性特征。
