Lee Hyun Jae, Hossain Rajib, Baek Chang-Heon, Lee Choong Jae, Hwang Sun-Chul
Smith Liberal Arts College and Department of Addiction Science, Graduate School, Sahmyook University, Seoul 01795, Republic of Korea.
Department of Pharmacology, College of Medicine, Chungnam National University, Daejeon 35015, Republic of Korea.
Biomol Ther (Seoul). 2025 Jan 1;33(1):86-94. doi: 10.4062/biomolther.2024.139. Epub 2024 Dec 5.
Current approaches to regulating osteoarthritis primarily focus on symptom management; however, these methods often have significant side effects and may not be suitable for long-term care. As an alternative to conventional treatments, injecting stem cells into knee joint cartilage is a promising option for repairing damaged cartilage. In this review, we outline the general procedure for stem cell treatment of knee joint cartilage regeneration, emphasizing the potential of intra-articular stem cell injections as a therapeutic option for osteoarthritis. We examined and summarized patient evaluation and preparation for knee joint stem cell therapy, stem cell harvesting, stem cell preparation, injection procedures for stem cell therapy, post-injection care and monitoring, potential outcomes of stem cell therapy, and considerations and risks associated with stem cell therapy. Overall, stem cell injections for knee joint cartilage damage represent a promising frontier in orthopedic care. They offer potential benefits such as pain and inflammation reduction, promotion of cartilage repair and regeneration, and the possibility of avoiding more invasive treatments such as knee surgery. Ongoing collaboration among researchers, clinicians, and regulatory organizations is crucial for advancing this field and translating scientific discoveries into effective clinical applications.
目前治疗骨关节炎的方法主要集中在症状管理上；然而，这些方法往往有显著的副作用，可能不适用于长期护理。作为传统治疗方法的替代方案，将干细胞注入膝关节软骨是修复受损软骨的一个有前景的选择。在这篇综述中，我们概述了干细胞治疗膝关节软骨再生的一般程序，强调关节内注射干细胞作为骨关节炎治疗选择的潜力。我们研究并总结了膝关节干细胞治疗的患者评估与准备、干细胞采集、干细胞制备、干细胞治疗的注射程序、注射后护理与监测、干细胞治疗的潜在结果，以及与干细胞治疗相关的注意事项和风险。总体而言，针对膝关节软骨损伤的干细胞注射是骨科护理中一个有前景的领域。它们具有潜在的益处，如减轻疼痛和炎症、促进软骨修复和再生，以及避免诸如膝关节手术等更具侵入性治疗的可能性。研究人员、临床医生和监管机构之间持续的合作对于推动该领域发展并将科学发现转化为有效的临床应用至关重要。
