Zhang Daxue, Zhang Yongli, Kang Jian, Li Xuchun
Department of Orthopaedics, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China.
Sci Rep. 2024 Dec 4;14(1):30223. doi: 10.1038/s41598-024-82068-5.
To investigate the non-linear relationship between diabetes mellitus (DM) duration and the development of diabetic retinopathy (DR). By investigating the association between these variables, our goal is to contribute to the existing knowledge regarding the impact of DM duration on the development and severity of DR. A retrospective cross-sectional study was conducted on 420 patients in the Department of Endocrinology at Guangdong Provincial People's Hospital, who had undergone ophthalmic consultations from December 2017 to November 2018. The analysis of DM duration and DR utilized a generalized additive model to identify both linear and non-linear connections. The threshold effect was determined using a two-piece regression model. The study included a total of 420 patients, with a mean age of 58.7 years. Of these, 56.9% (239/420) were male. The prevalence of DR was 38.33% (161/420). After adjusting for confounding factors, a nonlinear relationship between DM duration and DR was observed, with a turning point at 8 years. On the left side of the turning point, the prevalence increased by 24% per 1-year increase in DM duration (OR: 1.24; 95% CI: 1.11-1.38; P<0.0001). However, no statistically significant differences were found on the right side of the turning point (OR: 1.02; 95% CI: 0.97-1.08; P = 0.4987). Our study identified a non-linear relationship between DM duration and DR in patients. When the DM duration is less than 8 years, a positive correlation exists between DM duration and DR. However, once the DM duration exceeds 8 years, the effect reaches saturation, and no significant correlation is observed.
研究糖尿病（DM）病程与糖尿病视网膜病变（DR）发生之间的非线性关系。通过研究这些变量之间的关联，我们的目标是为现有关于DM病程对DR发生和严重程度影响的知识做出贡献。对广东省人民医院内分泌科2017年12月至2018年11月期间接受眼科会诊的420例患者进行了一项回顾性横断面研究。对DM病程和DR的分析采用广义相加模型来识别线性和非线性联系。使用两段回归模型确定阈值效应。该研究共纳入420例患者，平均年龄58.7岁。其中，56.9%（239/420）为男性。DR的患病率为38.33%（161/420）。在调整混杂因素后，观察到DM病程与DR之间存在非线性关系，转折点为8年。在转折点左侧，DM病程每增加1年，患病率增加24%（比值比：1.24；95%置信区间：1.11 - 1.38；P<0.0001）。然而，在转折点右侧未发现统计学上的显著差异（比值比：1.02；95%置信区间：0.97 - 1.08；P = 0.4987）。我们的研究确定了患者中DM病程与DR之间的非线性关系。当DM病程小于8年时，DM病程与DR之间存在正相关。然而，一旦DM病程超过8年，效应达到饱和，未观察到显著相关性。
