Viggiano Pasquale, Vujosevic Stela, Palumbo Francesca, Grassi Maria Oliva, Boscia Giacomo, Borrelli Enrico, Reibaldi Michele, Sborgia Luigi, Molfetta Teresa, Evangelista Federica, Alessio Giovanni, Boscia Francesco
Department of Translational Biomedicine Neuroscience, University of Bari "Aldo Moro", Bari, Piazza Giulio Cesare,11, Italy.
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.; Eye Clinic, IRCCS MultiMedica, Milan, Italy.
Photodiagnosis Photodyn Ther. 2024 Apr;46:104042. doi: 10.1016/j.pdpdt.2024.104042. Epub 2024 Mar 7.
to investigate the structural features and extended visual results in eyes affected by diabetic retinopathy (DR) and diabetic macular edema (DME) that have been successfully treated with anti-vascular endothelial growth factor (VEGF) therapy.
Individuals (39 eyes of 39 patients) who had undergone long-term follow-up and demonstrated evidence of resolved DME after at least 2 years of follow-up following the initiation of anti-VEGF therapy were included. During the ""study visit"", structural OCT scans were examined to assess qualitative features indicative of neuroretina or retinal pigment epithelium distress. Additionally, a quantitative assessment of the inner and outer retinal thicknesses was conducted for topographical analysis.
The most robust qualitative association observed with BCVA at the "study visit" was linked to the presence of DRIL (p = 0.043) and the appearance of the ELM. (p = 0.045). Regarding quantitative parameters, a strong correlation was noted between the visual acuity during the "study visit" and the foveal and parafoveal thicknesses of both the inner and outer retina (p < 0.001).
Changes in the status of ELM, the presence of DRIL, and the thicknesses of the foveal and parafoveal regions can act as OCT biomarkers, signifying prolonged visual improvements in eyes that have experienced resolved DME after undergoing anti-VEGF therapy.
研究已成功接受抗血管内皮生长因子（VEGF）治疗的糖尿病视网膜病变（DR）和糖尿病性黄斑水肿（DME）患者眼睛的结构特征及长期视觉效果。
纳入39例患者的39只眼睛，这些患者接受了长期随访，且在开始抗VEGF治疗后至少2年的随访中显示出DME消退的证据。在“研究访视”期间，检查结构光学相干断层扫描（OCT）以评估指示神经视网膜或视网膜色素上皮损伤的定性特征。此外，对视网膜内外层厚度进行定量评估以进行地形分析。
在“研究访视”时观察到的与最佳矫正视力（BCVA）最显著的定性关联与糖尿病视网膜病变内层局限性（DRIL）的存在（p = 0.043）和椭圆体带（ELM）的外观（p = 0.045）有关。关于定量参数，“研究访视”期间的视力与视网膜内外层的中央凹和旁中央凹厚度之间存在强相关性（p < 0.001）。
ELM状态的变化、DRIL的存在以及中央凹和旁中央凹区域的厚度可作为OCT生物标志物，表明接受抗VEGF治疗后DME消退的眼睛视觉改善持续时间延长。
