Pedersen S, Steffensen G
Allergy. 1986 Jan;41(1):46-50. doi: 10.1111/j.1398-9995.1986.tb00274.x.
The bioavailability and absorption pattern of theophylline from a single dose of a slow release theophylline sprinkle product (Somophyllin) were investigated in 10 asthmatic children both in fasting conditions and after a standardized breakfast. Theophylline given intravenously was used as a reference. The fasting absorption of Somophyllin was rather fast with peak serum theophylline levels 3-5 h (mean 3.7 h) after dosing. Food produced a small but statistically significant reduction in the rate of absorption of theophylline, so that the mean time to peak serum theophylline level was 5.6 h (range 4-8 h) after food. In no case was there any important difference between the absorption profiles on the test days, and the bioavailability was complete after both fasted and fed intake of the product (92.5% and 105%, respectively). It is suggested that to obtain the optimum absorption profile children should take Somophyllin with food rather than between meals.
在10名哮喘儿童中，研究了单剂量缓释茶碱撒布剂（舒弗美）在空腹状态和标准早餐后，茶碱的生物利用度和吸收模式。静脉注射茶碱用作对照。舒弗美在空腹时吸收相当快，给药后3 - 5小时（平均3.7小时）达到血清茶碱峰值水平。食物使茶碱的吸收速率有轻微但具有统计学意义的降低，因此进食后血清茶碱水平达到峰值的平均时间为5.6小时（范围4 - 8小时）。在测试日的吸收曲线之间，均未出现任何重要差异，且该产品在空腹和进食后摄入的生物利用度均达到完全状态（分别为92.5%和105%）。建议为获得最佳吸收曲线，儿童应在进食时服用舒弗美，而非在两餐之间服用。
