Pedersen S, Moeller-Petersen J
Allergy. 1982 Oct;37(7):531-4. doi: 10.1111/j.1398-9995.1982.tb02336.x.
Six children and six adults were given a single dose of a sustained release theophylline preparation (Nuelin Retard) after an overnight fast and later after a standardized breakfast. Food significantly reduced the absorption rate of theophylline whereas the extent of absorption of theophylline was unaffected by food. Under steady state treatment the fluctuations in the serum levels of theophylline were small when the tablets were taken after meals twice a day showing that this dose regimen was sufficient. No characteristic absorption or elimination phases were seen during the steady state dose interval, and the time to peak serum theophylline level showed great variation. Serum theophylline control about 4 h after fasting intake of the tablet is recommended.
六名儿童和六名成年人在禁食过夜后以及之后在标准化早餐后服用了单剂量的缓释茶碱制剂（Nuelin Retard）。食物显著降低了茶碱的吸收速率，而茶碱的吸收程度不受食物影响。在稳态治疗下，当片剂一天服用两次且饭后服用时，茶碱血清水平的波动较小，表明这种给药方案是足够的。在稳态剂量间隔期间未观察到特征性的吸收或消除阶段，并且血清茶碱水平达到峰值的时间有很大差异。建议在空腹服用片剂约4小时后进行血清茶碱监测。
