使用阿库氯铵诱导前预充后的插管条件。

Intubating conditions following pre-induction priming with alcuronium.

作者信息

Harrop-Griffiths A W, Grounds R M, Moore M

出版信息

Anaesthesia. 1986 Mar;41(3):282-6. doi: 10.1111/j.1365-2044.1986.tb12789.x.

DOI:10.1111/j.1365-2044.1986.tb12789.x

Abstract

Three priming doses of alcuronium have been investigated and, using a logistic transformation technique, the priming dose required to produce adequate intubating conditions in 99% of patients at 60 seconds following the second dose of alcuronium has been deduced. This dose, 106.5 micrograms/kg is extremely high and may be unsafe if used, since 30% of our patients complained of side effects when given a priming dose of only 50 micrograms/kg.

摘要

已对阿库氯铵的三次预注剂量进行了研究，并采用逻辑转换技术推导出在第二次注射阿库氯铵后60秒时，使99%的患者产生足够插管条件所需的预注剂量。该剂量为106.5微克/千克，极高，使用时可能不安全，因为我们的患者中30%在仅给予50微克/千克的预注剂量时就出现了副作用。