Gendolla Astrid, Brown Joshua D, Mercadante Amanda R, Drakeley Sheila, Sternbach Nikoletta, Jenkins Aaron, Hygge Blakeman Karin, Coppola Gianluca
Praxis Gendolla, Essen, Germany.
Pfizer Inc, New York, NY, USA.
Cephalalgia. 2024 Dec;44(12):3331024241276415. doi: 10.1177/03331024241276415.
Despite the high prevalence of migraine in Europe, there is limited research on the burden among people with migraine.
This cross-sectional survey used patient-reported data from the 2020 European National Health and Wellness Survey in France, Germany, Italy, Spain, and the United Kingdom. The study assessed the sociodemographic characteristics, health-related quality of life, depression, work productivity and activity impairment, and healthcare resource utilization among matched samples of people with diagnosed migraine (n = 3985) and compared to a matched cohort without migraine (n = 7970). The study also analyzed the burden across migraine subgroups stratified by the number of migraine headache days.
Lower health-related quality of life, higher depression, increased work productivity and activity impairment, and higher healthcare resource utilization were reported among people with migraine and ≥1 migraine headache days compared to matched people without migraine (all < 0.001). Additionally, the incremental burden was also observed across migraine subgroups (1-3, 4-7, 8-14, and ≥15 migraine headache days) irrespective of the use of prescription medication compared to the matched controls without migraine.
Migraine sufferers with ≥1 migraine headache days experienced worse productivity, lower quality of life, depression, and increased healthcare resource utilization than those without migraine, emphasizing the need for effective management strategies.
尽管偏头痛在欧洲的患病率很高,但关于偏头痛患者负担的研究却很有限。
这项横断面调查使用了来自2020年法国、德国、意大利、西班牙和英国欧洲国民健康与幸福调查中患者报告的数据。该研究评估了确诊为偏头痛的匹配样本(n = 3985)的社会人口学特征、健康相关生活质量、抑郁、工作生产力和活动障碍以及医疗资源利用情况,并与无偏头痛的匹配队列(n = 7970)进行比较。该研究还分析了按偏头痛头痛天数分层的偏头痛亚组的负担情况。
与无偏头痛的匹配人群相比,有偏头痛且偏头痛头痛天数≥1天的人群报告的健康相关生活质量较低、抑郁程度较高、工作生产力和活动障碍增加以及医疗资源利用较高(所有P < 0.001)。此外,与无偏头痛的匹配对照组相比,无论是否使用处方药,在偏头痛亚组(1 - 3天、4 - 7天、8 - 14天和≥15天偏头痛头痛天数)中也观察到了额外的负担。
与无偏头痛的人相比,偏头痛头痛天数≥1天的偏头痛患者经历了更差的生产力、更低的生活质量、抑郁以及更高的医疗资源利用,强调了有效管理策略的必要性。