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Depletion of the RNA binding protein QKI and circular RNA dysregulation in T-cell acute lymphoblastic leukemia.

作者信息

Buratin Alessia, Palhais Bruno, Gaffo Enrico, Roels Juliette, Morscio Julie, Van Laere Jolien, Orsi Silvia, Te Kronnie Geertruij, Van Vlierberghe Pieter, Ntziachristos Panagiotis, Bortoluzzi Stefania

机构信息

Department of Molecular Medicine, University of Padova, Padova.

Leukemia Therapy Resistance Unit, Department of Biomolecular Medicine, Ghent University, Ghent, Belgium; Center for Medical Genetics, Ghent University and University Hospital, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent.

出版信息

Haematologica. 2025 Apr 1;110(4):972-979. doi: 10.3324/haematol.2024.285971. Epub 2024 Dec 5.

DOI:10.3324/haematol.2024.285971
PMID:39633556
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11959247/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23ed/11959247/39b4cc7e6e5e/110972.fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23ed/11959247/1c34b83c7bf8/110972.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23ed/11959247/e394ae9cb30f/110972.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23ed/11959247/39b4cc7e6e5e/110972.fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23ed/11959247/1c34b83c7bf8/110972.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23ed/11959247/e394ae9cb30f/110972.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23ed/11959247/39b4cc7e6e5e/110972.fig3.jpg

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本文引用的文献

1
CircRNA: a rising star in leukemia.环状 RNA：白血病领域的后起之秀。
PeerJ. 2023 Jul 6;11:e15577. doi: 10.7717/peerj.15577. eCollection 2023.
2
Novel hypoxia-induced HIF1α-circTDRD3-positive feedback loop promotes the growth and metastasis of colorectal cancer.新型缺氧诱导的 HIF1α-circTDRD3 正反馈环促进结直肠癌的生长和转移。
Oncogene. 2023 Jan;42(3):238-252. doi: 10.1038/s41388-022-02548-8. Epub 2022 Nov 22.
3
Estrogen receptor beta increases clear cell renal cell carcinoma stem cell phenotype via altering the circPHACTR4/miR-34b-5p/c-Myc signaling.
雌激素受体β通过改变 circPHACTR4/miR-34b-5p/c-Myc 信号通路增加透明细胞肾细胞癌干细胞表型。
FASEB J. 2022 Feb;36(2):e22163. doi: 10.1096/fj.202101645R.
4
CircRTN4 promotes pancreatic cancer progression through a novel CircRNA-miRNA-lncRNA pathway and stabilizing epithelial-mesenchymal transition protein.环状 RNA RTN4 通过新型环状 RNA-miRNA-长链非编码 RNA 通路促进胰腺癌进展并稳定上皮-间充质转化蛋白。
Mol Cancer. 2022 Jan 4;21(1):10. doi: 10.1186/s12943-021-01481-w.
5
Sensitive, reliable and robust circRNA detection from RNA-seq with CirComPara2.CirComPara2 实现了从 RNA-seq 中灵敏、可靠且稳健的环状 RNA 检测。
Brief Bioinform. 2022 Jan 17;23(1). doi: 10.1093/bib/bbab418.
6
Silencing of circTASP1 inhibits proliferation and induces apoptosis of acute myeloid leukaemia cells through modulating miR-515-5p/HMGA2 axis.circTASP1 通过调控 miR-515-5p/HMGA2 轴抑制急性髓系白血病细胞增殖并诱导其凋亡。
J Cell Mol Med. 2021 Aug;25(15):7367-7380. doi: 10.1111/jcmm.16765. Epub 2021 Jul 1.
7
Large-scale circular RNA deregulation in T-ALL: unlocking unique ectopic expression of molecular subtypes.T 细胞急性淋巴细胞白血病中大规模环状 RNA 失调：揭示分子亚型独特的异位表达
Blood Adv. 2020 Dec 8;4(23):5902-5914. doi: 10.1182/bloodadvances.2020002337.
8
A comprehensive inventory of TLX1 controlled long non-coding RNAs in T-cell acute lymphoblastic leukemia through polyA+ and total RNA sequencing.通过聚腺苷酸加尾RNA（polyA+）和总RNA测序全面鉴定T细胞急性淋巴细胞白血病中TLX1调控的长链非编码RNA。
Haematologica. 2018 Dec;103(12):e585-e589. doi: 10.3324/haematol.2018.190587. Epub 2018 Jun 28.
9
CirComPara: A Multi-Method Comparative Bioinformatics Pipeline to Detect and Study circRNAs from RNA-seq Data.CirComPara：一种用于从RNA测序数据中检测和研究环状RNA的多方法比较生物信息学流程
Noncoding RNA. 2017 Feb 10;3(1):8. doi: 10.3390/ncrna3010008.
10
CircRNAs in hematopoiesis and hematological malignancies.造血作用和血液系统恶性肿瘤中的环状RNA
Blood Cancer J. 2016 Oct 14;6(10):e483. doi: 10.1038/bcj.2016.81.