微小RNA与高血压
microRNA and Hypertension.
作者信息
He Lishu, Liu Yong, Widlansky Michael E, Kriegel Alison J, Qiu Qiongzi, Liang Mingyu
机构信息
Department of Physiology, University of Arizona College of Medicine-Tucson (L.H., Y.L., Q.Q., M.L.).
Department of Physiology (L.H., A.J.K.), Medical College of Wisconsin, Milwaukee.
出版信息
Hypertension. 2025 Feb;82(2):181-184. doi: 10.1161/HYPERTENSIONAHA.124.21728. Epub 2024 Dec 5.
Abstract
Several microRNAs (miRNAs) strongly influence blood pressure and the development of hypertension by modulating vascular, renal, and other physiological mechanisms. In addition, miRNAs may contribute to the genetic regulation of blood pressure. Future research should focus on investigating select miRNAs with potent physiological effects, understanding cellular context-dependent mechanisms conferring specificity to miRNA action, and integrating miRNAs as powerful modulators into the molecular system that underlies the regulation of blood pressure and the development of hypertension.
摘要
几种微小RNA（miRNA）通过调节血管、肾脏及其他生理机制，对血压及高血压的发展产生强烈影响。此外，miRNA可能参与血压的遗传调控。未来的研究应聚焦于研究具有强大生理效应的特定miRNA，理解赋予miRNA作用特异性的细胞背景依赖性机制，并将miRNA作为强大的调节因子整合到血压调节和高血压发展的分子系统中。
相似文献
1
microRNA and Hypertension.微小RNA与高血压
Hypertension. 2025 Feb;82(2):181-184. doi: 10.1161/HYPERTENSIONAHA.124.21728. Epub 2024 Dec 5.
2
A MicroRNA Screen Identifies the Wnt Signaling Pathway as a Regulator of the Interferon Response during Flavivirus Infection.一项微小RNA筛选确定Wnt信号通路是黄病毒感染期间干扰素反应的调节因子。
J Virol. 2017 Mar 29;91(8). doi: 10.1128/JVI.02388-16. Print 2017 Apr 15.
3
Blood pressure targets for hypertension in people with chronic renal disease.高血压合并慢性肾脏病患者的血压目标。
Cochrane Database Syst Rev. 2024 Oct 15;10(10):CD008564. doi: 10.1002/14651858.CD008564.pub3.
4
MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis.支气管肺发育不良的微小RNA表达谱研究：一项系统评价和荟萃分析。
Genet Mol Res. 2013 Oct 30;12(4):5195-206. doi: 10.4238/2013.October.30.4.
5
Effect of cocoa on blood pressure.可可对血压的影响。
Cochrane Database Syst Rev. 2012 Aug 15(8):CD008893. doi: 10.1002/14651858.CD008893.pub2.
6
Peripheral Blood miRNA Expression in Patients with Essential Hypertension in the Han Chinese Population in Hefei, China.中国合肥汉族人群原发性高血压患者外周血miRNA表达情况
Biochem Genet. 2024 Jun 21. doi: 10.1007/s10528-024-10867-6.
7
Methionine supplementation-induced alteration of sheep seminal plasma miRNAs and proteome.蛋氨酸补充诱导绵羊精浆微小RNA和蛋白质组的改变。
J Anim Sci. 2025 Jan 4;103. doi: 10.1093/jas/skaf192.
8
A comprehensive investigation of identifying miRNA biomarkers and their potential role in age-related cataract by meta-analysis and bioinformatics analysis.通过荟萃分析和生物信息学分析全面研究鉴定与年龄相关性白内障相关的miRNA生物标志物及其潜在作用。
Graefes Arch Clin Exp Ophthalmol. 2025 Jan 6. doi: 10.1007/s00417-024-06723-3.
9
Cardiovascular and neuroimmune adaptations to enalapril and exercise training: A comparative study in male and ovariectomized female spontaneously hypertensive rats.依那普利与运动训练对心血管和神经免疫的适应性：雄性和去卵巢雌性自发性高血压大鼠的比较研究
Auton Neurosci. 2025 Aug;260:103280. doi: 10.1016/j.autneu.2025.103280. Epub 2025 Apr 12.
10
Advances in Genomics Research of Blood Pressure Responses to Dietary Sodium and Potassium Intakes.膳食钠钾摄入与血压反应的基因组学研究进展。
Hypertension. 2021 Jul;78(1):4-15. doi: 10.1161/HYPERTENSIONAHA.121.16509. Epub 2021 May 17.
引用本文的文献
1
Pharmacoepigenomic Impact of Antihypertensive Drugs on miRNome and Proteome and Its Potential Influence on Health and Side Effects.抗高血压药物对微小RNA组和蛋白质组的药物表观基因组学影响及其对健康和副作用的潜在影响。
Cells. 2025 Aug 31;14(17):1359. doi: 10.3390/cells14171359.
2
Involvement of miRNAs in the Cluster of Metabolic Factors of MetS: Nutrition-Genome-MetS Axis.微小RNA在代谢综合征代谢因子簇中的作用：营养-基因组-代谢综合征轴
J Clin Med. 2025 Jun 14;14(12):4234. doi: 10.3390/jcm14124234.
本文引用的文献
1
MicroRNA-19 is regulated by aldosterone in a sex-specific manner to alter kidney sodium transport.miR-19 受醛固酮以性别特异性方式调控，从而改变肾脏钠转运。
Am J Physiol Cell Physiol. 2024 Jan 1;326(1):C282-C293. doi: 10.1152/ajpcell.00385.2023. Epub 2023 Dec 4.
2
microRNAs in action: biogenesis, function and regulation.微小 RNA 在行动中：生物发生、功能和调节。
Nat Rev Genet. 2023 Dec;24(12):816-833. doi: 10.1038/s41576-023-00611-y. Epub 2023 Jun 28.
3
MicroRNA-195a-5p Regulates Blood Pressure by Inhibiting NKCC2A.微小 RNA-195a-5p 通过抑制 NKCC2A 调节血压。
Hypertension. 2023 Feb;80(2):426-439. doi: 10.1161/HYPERTENSIONAHA.122.19794. Epub 2022 Nov 30.
4
Deficiency of MicroRNA-181a Results in Transcriptome-Wide Cell-Specific Changes in the Kidney and Increases Blood Pressure.miR-181a 缺失导致肾脏转录组细胞特异性变化，并增加血压。
Hypertension. 2021 Nov;78(5):1322-1334. doi: 10.1161/HYPERTENSIONAHA.121.17384. Epub 2021 Sep 20.
5
Pathological Bases and Clinical Application of Long Noncoding RNAs in Cardiovascular Diseases.长链非编码 RNA 在心血管疾病中的病理基础及临床应用。
Hypertension. 2021 Jul;78(1):16-29. doi: 10.1161/HYPERTENSIONAHA.120.16752. Epub 2021 Jun 1.
6
MicroRNA-133a-Dependent Inhibition of Proximal Tubule Angiotensinogen by Renal TNF (Tumor Necrosis Factor).MicroRNA-133a 通过肾脏 TNF（肿瘤坏死因子）抑制近端小管血管紧张素原。
Hypertension. 2020 Dec;76(6):1744-1752. doi: 10.1161/HYPERTENSIONAHA.120.15435. Epub 2020 Nov 2.
7
Endogenous miR-204 Protects the Kidney against Chronic Injury in Hypertension and Diabetes.内源性 miR-204 保护肾脏免受高血压和糖尿病的慢性损伤。
J Am Soc Nephrol. 2020 Jul;31(7):1539-1554. doi: 10.1681/ASN.2019101100. Epub 2020 Jun 2.
8
T-Cell-Derived miRNA-214 Mediates Perivascular Fibrosis in Hypertension.T 细胞来源的 microRNA-214 介导高血压中的血管周围纤维化。
Circ Res. 2020 Apr 10;126(8):988-1003. doi: 10.1161/CIRCRESAHA.119.315428. Epub 2020 Feb 17.
9
Comparative and Functional Genomic Resource for Mechanistic Studies of Human Blood Pressure-Associated Single Nucleotide Polymorphisms.人类血压相关单核苷酸多态性的机制研究比较和功能基因组资源。
Hypertension. 2020 Mar;75(3):859-868. doi: 10.1161/HYPERTENSIONAHA.119.14109. Epub 2020 Jan 6.
10
Noncoding RNAs in Hypertension.高血压中的非编码RNA
Hypertension. 2019 Sep;74(3):477-492. doi: 10.1161/HYPERTENSIONAHA.119.13412. Epub 2019 Jul 29.
Zotero 插件