He Lishu, Liu Yong, Widlansky Michael E, Kriegel Alison J, Qiu Qiongzi, Liang Mingyu
Department of Physiology, University of Arizona College of Medicine-Tucson (L.H., Y.L., Q.Q., M.L.).
Department of Physiology (L.H., A.J.K.), Medical College of Wisconsin, Milwaukee.
Hypertension. 2025 Feb;82(2):181-184. doi: 10.1161/HYPERTENSIONAHA.124.21728. Epub 2024 Dec 5.
Several microRNAs (miRNAs) strongly influence blood pressure and the development of hypertension by modulating vascular, renal, and other physiological mechanisms. In addition, miRNAs may contribute to the genetic regulation of blood pressure. Future research should focus on investigating select miRNAs with potent physiological effects, understanding cellular context-dependent mechanisms conferring specificity to miRNA action, and integrating miRNAs as powerful modulators into the molecular system that underlies the regulation of blood pressure and the development of hypertension.
几种微小RNA（miRNA）通过调节血管、肾脏及其他生理机制，对血压及高血压的发展产生强烈影响。此外，miRNA可能参与血压的遗传调控。未来的研究应聚焦于研究具有强大生理效应的特定miRNA，理解赋予miRNA作用特异性的细胞背景依赖性机制，并将miRNA作为强大的调节因子整合到血压调节和高血压发展的分子系统中。
