Omeje Ifesinachi Joy, Takai Idris Usman, Sunday Achanya Ememona, Abdurrahman Aisha, Ntoimo Lorretta Favour Chizomam, Ifanayajo Oluwafemi Oluwaseun
Department of Obstetrics and Gynaecology Aminu Kano Teaching Hospital Kano, Kano State, Nigeria.
Department of Obstetrics and Gynaecology, Aminu Kano Teaching Hospital Kano/ Bayero University Kano, Kano State, Nigeria.
Niger Med J. 2024 Nov 6;65(5):749-760. doi: 10.60787/nmj-v65i3.552. eCollection 2024 Sep-Oct.
Hyperprolactinaemia can cause infertility. Serum prolactin and clinical features of hyperprolactinaemia may vary between obese and non-obese infertile women. Identifying the differences may inform changes in the management of obese women with hyperprolactinaemia. This study aimed to compare the serum prolactin levels and the clinical features of hyperprolactinaemia in obese and non-obese infertile women in Kano.
This was a comparative cross-sectional study comprising 160 obese infertile women (study group) and another 160 non-obese infertile women (control group). Participants were recruited in the gynaecology clinics of Aminu Kano Teaching Hospital (AKTH) and Murtala Muhammed specialist Hospital (MMSH). Serum prolactin and clinical features of those with hyperprolactinaemia were analysed using SPSS 23. P-values ≤ 0.05 were considered significant. Odd ratios at 95% confidence were calculated.
The mean serum prolactin levels were 28.18 ± 10.53ng/ml and 17.50 ± 8.00 ng/ml in the obese and non-obese women respectively (P=0.0001). All categories of hyperprolactinaemia were more common (P=0.001) amongst the obese infertile women. The prevalence of hyperprolactinaemia was 37.5% and 18.1% in the obese and non-obese arms respectively (P=0.0001). However, 23.1% obese hyperprolactinaemic infertile women presented with galactorrhoea compared to 64.0% of the non-obese counterparts (P= 0.0001). Abnormal menstrual flow and galactorrhoea were observed more in moderate-markedly elevated serum prolactin level as seen in 65.2% and 69.6% respectively compared to those with mildly elevated serum prolactin level.
Obese infertile women have higher baseline and prevalence of hyperprolactinaemia than their non-obese counterparts. However, non-obese hyperprolactinaemic infertile women presented more with galactorrhoea.
高催乳素血症可导致不孕。肥胖和非肥胖不孕女性的血清催乳素水平及高催乳素血症的临床特征可能有所不同。明确这些差异可能为肥胖型高催乳素血症女性的治疗管理变化提供依据。本研究旨在比较卡诺地区肥胖和非肥胖不孕女性的血清催乳素水平及高催乳素血症的临床特征。
这是一项比较性横断面研究，包括160名肥胖不孕女性（研究组）和另外160名非肥胖不孕女性（对照组）。研究对象在阿明努·卡诺教学医院（AKTH）和穆尔塔拉·穆罕默德专科医院（MMSH）的妇科诊所招募。使用SPSS 23分析高催乳素血症患者的血清催乳素水平和临床特征。P值≤0.05被认为具有统计学意义。计算95%置信区间的比值比。
肥胖和非肥胖女性的平均血清催乳素水平分别为28.18±10.53ng/ml和17.50±8.00 ng/ml（P=0.0001）。各类高催乳素血症在肥胖不孕女性中更为常见（P=0.001）。肥胖组和非肥胖组的高催乳素血症患病率分别为37.5%和18.1%（P=0.0001）。然而，23.1%的肥胖高催乳素血症不孕女性出现溢乳，而非肥胖组为64.0%（P=0.0001）。与血清催乳素水平轻度升高的患者相比，血清催乳素水平中度至明显升高的患者中，月经异常和溢乳更为常见，分别为65.2%和69.6%。
肥胖不孕女性的高催乳素血症基线水平和患病率高于非肥胖不孕女性。然而，非肥胖高催乳素血症不孕女性溢乳症状更为多见。
