Boozhmehrani Mohammad Javad, Bahreiny Seyed Sobhan, Bastani Mohammad Navid, Amraei Mahdi, Mansouri Zahra, Kazemzadeh Razieh, Farhadi Majid, Hoseinnejad Akbar, Pirsadeghi Ali, Asadi Zahra, Bighamian Afshin, Eslami Gilda
Department of Medical Parasitology, Faculty of Medicine Jundishapur University of Medical Sciences Ahvaz Iran.
Student Research Committee Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran.
Health Sci Rep. 2024 Dec 4;7(12):e70235. doi: 10.1002/hsr2.70235. eCollection 2024 Dec.
Pulmonary hydatid disease, caused by , presents significant clinical challenges, particularly in pediatric populations. Surgical intervention remains the gold standard for treatment, with various techniques employed, including capitonnage and non-capitonnage methods. This systematic review and meta-analysis evaluates the efficacy and safety of capitonnage compared to non-capitonnage techniques in children.
This systematic review and meta-analysis followed the PRISMA guidelines to ensure methodological rigor. A comprehensive literature search was conducted across PubMed, Web of Science, and Scopus databases to identify relevant studies. To assess pooled event rates and corresponding 95% confidence intervals for both complications and cure rates, we employed a random-effects model, allowing for variability among study populations. All statistical analyses were conducted using Comprehensive Meta-Analysis software (version 3.7).
Thirteen studies met the established inclusion criteria for analysis. The overall complication rate was 46%, with significantly lower rates in the capitonnage group (24%) compared to the non-capitonnage group (58%). The cure rate was higher in the capitonnage group (83.5%) than in the non-capitonnage group (65.2%). Meta-regression analysis indicated that complication rates were influenced by cyst diameter, study publication date, mean age, and type of surgery.
The findings suggest that capitonnage is associated with better outcomes in terms of lower complication rates and higher cure rates. This evidence supports the use of capitonnage as a preferred surgical technique for managing pulmonary hydatid disease in children. Further research is recommended to explore the long-term outcomes and potential benefits of combining surgical and pharmacological treatments.
由[未提及具体病因]引起的肺包虫病带来了重大的临床挑战，尤其是在儿童群体中。手术干预仍然是治疗的金标准，采用了多种技术，包括内翻缝合和非内翻缝合方法。本系统评价和荟萃分析评估了内翻缝合与非内翻缝合技术在儿童中的疗效和安全性。
本系统评价和荟萃分析遵循PRISMA指南以确保方法的严谨性。在PubMed、科学网和Scopus数据库中进行了全面的文献检索，以识别相关研究。为了评估并发症和治愈率的合并事件发生率及相应的95%置信区间，我们采用了随机效应模型，以考虑研究人群之间的变异性。所有统计分析均使用综合荟萃分析软件（版本3.7）进行。
13项研究符合既定的纳入分析标准。总体并发症发生率为46%，内翻缝合组（24%）的发生率显著低于非内翻缝合组（58%）。内翻缝合组的治愈率（83.5%）高于非内翻缝合组（65.2%）。荟萃回归分析表明，并发症发生率受囊肿直径、研究发表日期、平均年龄和手术类型的影响。
研究结果表明，内翻缝合在降低并发症发生率和提高治愈率方面具有更好的效果。这一证据支持将内翻缝合作为治疗儿童肺包虫病的首选手术技术。建议进一步研究探索手术和药物联合治疗的长期效果和潜在益处。
