Oikonomidis Ioannis L, Antoniadis Harris, Papathanasiou Afroditi, Tsouloufi Theodora K, Kousi Timokleia, Kalafati Maria Rafaella, Kritsepi-Konstantinou Maria
School of Veterinary Medicine Faculty of Health Sciences Aristotle University of Thessaloniki Thessaloniki Greece.
Department of Veterinary Anatomy, Physiology and Pathology Institute of Infection Veterinary and Ecological Sciences University of Liverpool, Wirral Neston UK.
Vet Rec Open. 2024 Dec 3;11(2):e70000. doi: 10.1002/vro2.70000. eCollection 2024 Dec.
The aetiology of increased mean platelet volume in dogs is currently uncertain. Our aim was to investigate the aetiology of increased mean platelet volume in dogs with and without thrombocytopenia.
The database of a teaching hospital was retrospectively searched for dogs with increased mean platelet volume (>14.4 fL) over a 3-year period. Complete blood counts were performed with an Advia 120 analyser. Cases with incomplete medical records or belonging to breeds known to be associated with macrothrombocytopenia were excluded.
Sixty-six dogs were included, with Group 1 consisting of non-thrombocytopenic dogs (49/66, 74.2%) and Group 2 consisting of thrombocytopenic dogs (17/66, 25.8%). Diagnoses significantly differed between the two groups ( = 0.003). In Group 1, inflammatory/infectious diseases (69.4%) were the most common cause, followed by neoplastic diseases (8.2%) and diabetes mellitus (6.1%). Dogs in Group 2 were diagnosed with either inflammatory/infectious diseases (50.0%) or neoplastic diseases (50.0%). The small sample size- and a potential delayed haematological analysis of some of the blood samples, could have artifactually affected the mean platelet volume.
In dogs with thrombocytopenia and increased mean platelet volume, inflammatory/infectious or neoplastic diseases should be considered. In non-thrombocytopenic dogs, increased mean platelet volume is primarily associated with inflammatory/infectious diseases, with neoplasia and diabetes mellitus being infrequent causes.
目前犬平均血小板体积增加的病因尚不确定。我们的目的是研究有和无血小板减少症的犬平均血小板体积增加的病因。
回顾性检索一家教学医院数据库中3年内平均血小板体积增加（>14.4 fL）的犬。使用Advia 120分析仪进行全血细胞计数。排除病历不完整或属于已知与大血小板减少症相关品种的病例。
纳入66只犬，第1组为非血小板减少症犬（49/66，74.2%），第2组为血小板减少症犬（17/66，25.8%）。两组间诊断有显著差异（P = 0.003）。在第1组中，炎症/感染性疾病（69.4%）是最常见原因，其次是肿瘤性疾病（8.2%）和糖尿病（6.1%）。第2组犬被诊断为炎症/感染性疾病（50.0%）或肿瘤性疾病（50.0%）。样本量小以及部分血样可能存在血液学分析延迟，可能会人为影响平均血小板体积。
对于血小板减少且平均血小板体积增加的犬，应考虑炎症/感染性或肿瘤性疾病。在非血小板减少症犬中，平均血小板体积增加主要与炎症/感染性疾病相关，肿瘤和糖尿病是少见原因。
