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变革X射线成像:通过级联工程方法迈向超低剂量检测的飞跃。

Revolutionizing X-ray Imaging: A Leap toward Ultra-Low-Dose Detection with a Cascade-Engineered Approach.

作者信息

Song Xin, Zhang Xinyuan, He Tengyue, Wang Jiayi, Zhu Hongwei, Zhou Renqian, Ahmad Taimoor, Bakr Osman M, Mohammed Omar F

机构信息

Center of Excellence for Renewable Energy and Storage Technologies, Division of Physical Science and Engineering, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia.

出版信息

ACS Cent Sci. 2024 Nov 13;10(11):2082-2089. doi: 10.1021/acscentsci.4c01296. eCollection 2024 Nov 27.

DOI:10.1021/acscentsci.4c01296
PMID:39634221
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11613229/
Abstract

X-ray detection technology is essential in various fields, including medical imaging and security checks. However, exposure to large doses of X-rays poses considerable health risks. Therefore, it is crucial to reduce the radiation dosage without compromising detection efficiency. To address this concern, we propose an innovative cascade-engineered approach that uses two interconnected single-crystal devices to mitigate dark current and enhance the detection limit. Using laboratory-grown methylammonium lead bromide (MAPbBr) perovskite single crystals, we engineered devices that significantly reduced detection thresholds and improved signal-to-noise ratios (SNRs). The detection threshold dropped from 590 nGy·s with the conventional method to 100 nGy·s using the cascade approach, surpassing the most recent record of 500 nGy·s achieved for MAPbBr devices under nearly identical conditions. The dark current was halved compared to that of conventional devices, and spatial resolution improved from 5.6 to 8.5 lp·mm. Imaging trials confirmed improved resolution and effectiveness at low doses, highlighting the approach's potential for medical diagnostics that prioritizes reducing radiation exposure without compromising image quality. The groundbreaking nature of this approach is highlighted by its adaptability across diverse electrical environments and crystal types, as evident in CdTe crystals, indicating its potential for widespread utilization in low-dose leakage monitoring and commercial X-ray devices.

摘要

X射线检测技术在包括医学成像和安全检查在内的各个领域都至关重要。然而,暴露于大剂量X射线下会带来相当大的健康风险。因此,在不影响检测效率的情况下降低辐射剂量至关重要。为了解决这一问题,我们提出了一种创新的级联工程方法,该方法使用两个相互连接的单晶器件来减轻暗电流并提高检测限。我们使用实验室生长的甲基溴化铅(MAPbBr)钙钛矿单晶制造了器件,这些器件显著降低了检测阈值并提高了信噪比(SNR)。检测阈值从传统方法的590 nGy·s降至级联方法的100 nGy·s,超过了在几乎相同条件下MAPbBr器件最近达到的500 nGy·s的记录。与传统器件相比,暗电流减半,空间分辨率从5.6 lp·mm提高到8.5 lp·mm。成像试验证实了在低剂量下分辨率和有效性的提高,突出了该方法在优先减少辐射暴露而不影响图像质量的医学诊断中的潜力。这种方法的开创性体现在其对不同电气环境和晶体类型的适应性上,如碲化镉晶体所示,表明其在低剂量泄漏监测和商用X射线设备中广泛应用的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bed/11613229/27d25f4f85b2/oc4c01296_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bed/11613229/957fbbdc73d2/oc4c01296_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bed/11613229/939ffa4883d0/oc4c01296_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bed/11613229/7e2b102969c1/oc4c01296_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bed/11613229/27d25f4f85b2/oc4c01296_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bed/11613229/957fbbdc73d2/oc4c01296_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bed/11613229/939ffa4883d0/oc4c01296_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bed/11613229/7e2b102969c1/oc4c01296_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bed/11613229/27d25f4f85b2/oc4c01296_0004.jpg

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本文引用的文献

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