Yu Liang, Bao Shiming, Zhu Feng, Xu Yanyan, Liu Yanwei, Jiang Runben, Yang Chuang, Cao Feng, Chen Wei, Li Pengtao
Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei City, China.
Department of General Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei City, China.
Front Nutr. 2024 Nov 20;11:1479800. doi: 10.3389/fnut.2024.1479800. eCollection 2024.
Gastric cancer (GC) remains a malignancy with high incidence and mortality rates worldwide. Although branched-chain amino acids (BCAAs) play a crucial role in various physiological and pathological processes, their specific relationship with risk of GC remains unclear.
We conducted a large-scale prospective cohort from UK Biobank database. We evaluated the relationship between BCAA levels and risk of GC using Cox regression, Kaplan-Meier survival curves, the accelerated failure time (AFT) model, and restricted cubic spline (RCS) analysis.
During the follow-up of 12 years, 247,753 participants were included in the study. And the Cox regression analysis revealed that higher levels of isoleucine (HR = 0.65, 95% CI 0.48-0.89; = 0.007), leucine (HR = 0.57, 95% CI 0.42-0.79; < 0.001), valine (HR = 0.53, 95% CI 0.39-0.73; < 0.001), and total BCAAs were associated with a reduced risk of GC (HR = 0.51, 95% CI 0.37-0.70; < 0.001). Kaplan-Meier curves and the AFT model confirmed that elevated BCAA levels significantly delayed the onset of GC. Additionally, RCS analysis identified nonlinear dose-response relationships between BCAAs and risk of GC. Stratified analyses indicated that the protective effect of BCAAs was consistent across various subgroups, with a more pronounced impact in older individuals without chronic diseases.
Elevated BCAA levels are significantly associated with a reduced risk of GC, particularly in older adults. This finding highlights the potential of BCAAs in GC prevention and suggests that future research and clinical practice should emphasize regulating BCAA levels.
胃癌（GC）在全球范围内仍是一种发病率和死亡率都很高的恶性肿瘤。尽管支链氨基酸（BCAAs）在各种生理和病理过程中起着至关重要的作用，但其与胃癌风险的具体关系仍不清楚。
我们从英国生物银行数据库中进行了一项大规模前瞻性队列研究。我们使用Cox回归、Kaplan-Meier生存曲线、加速失效时间（AFT）模型和限制立方样条（RCS）分析来评估BCAAs水平与胃癌风险之间的关系。
在12年的随访期间，共有247,753名参与者纳入研究。Cox回归分析显示，异亮氨酸水平较高（HR = 0.65，95%CI 0.48 - 0.89；P = 0.007）、亮氨酸（HR = 0.57，95%CI 0.42 - 0.79；P < 0.001）、缬氨酸（HR = 0.53，95%CI 0.39 - 0.73；P < 0.001）以及总的BCAAs与胃癌风险降低相关（HR = 0.51，95%CI 0.37 - 0.70；P < 0.001）。Kaplan-Meier曲线和AFT模型证实，升高的BCAAs水平显著延迟了胃癌的发病。此外，RCS分析确定了BCAAs与胃癌风险之间的非线性剂量反应关系。分层分析表明，BCAAs的保护作用在各个亚组中是一致的，在无慢性疾病的老年人中影响更为显著。
升高的BCAAs水平与降低的胃癌风险显著相关，尤其是在老年人中。这一发现凸显了BCAAs在胃癌预防中的潜力，并表明未来的研究和临床实践应强调调节BCAAs水平。
