Department of Gastroenterology, Zhejiang Provincial Clinical Research Center for Digestive Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Department of Gastroenterology, the First Affiliated Hospital of Ningbo University, Ningbo, 315010, China.
Nat Commun. 2024 May 2;15(1):3707. doi: 10.1038/s41467-024-47960-8.
Nuclear magnetic resonance (NMR)-based plasma fatty acids are objective biomarkers of many diseases. Herein, we aim to explore the associations of NMR-based plasma fatty acids with the risk of hepatocellular carcinoma (HCC) and chronic liver disease (CLD) mortality in 252,398 UK Biobank participants. Here we show plasma levels of n-3 poly-unsaturated fatty acids (PUFA) and n-6 PUFA are negatively associated with the risk of incident HCC [HR: 0.48 (95% CI: 0.33-0.69) and 0.48 (95% CI: 0.28-0.81), respectively] and CLD mortality [HR: 0.21 (95% CI: 0.13-0.33) and 0.15 (95% CI: 0.08-0.30), respectively], whereas plasma levels of saturated fatty acids are positively associated with these outcomes [HR: 3.55 (95% CI: 2.25-5.61) for HCC and 6.34 (95% CI: 3.68-10.92) for CLD mortality]. Furthermore, fibrosis stage significantly modifies the associations between PUFA and CLD mortality. This study contributes to the limited prospective evidence on the associations between plasma-specific fatty acids and end-stage liver outcomes.
基于核磁共振（NMR）的血浆脂肪酸是许多疾病的客观生物标志物。在此，我们旨在探索基于 NMR 的血浆脂肪酸与 252398 名英国生物库参与者肝细胞癌（HCC）和慢性肝病（CLD）死亡率风险的关联。我们在此展示了 n-3 多不饱和脂肪酸（PUFA）和 n-6 PUFA 的血浆水平与 HCC 发病风险呈负相关[HR：0.48（95%CI：0.33-0.69）和 0.48（95%CI：0.28-0.81）]和 CLD 死亡率[HR：0.21（95%CI：0.13-0.33）和 0.15（95%CI：0.08-0.30）]，而饱和脂肪酸的血浆水平与这些结果呈正相关[HR：HCC 的 3.55（95%CI：2.25-5.61）和 CLD 死亡率的 6.34（95%CI：3.68-10.92）]。此外，纤维化阶段显著改变了 PUFA 与 CLD 死亡率之间的关联。本研究为有限的前瞻性证据提供了补充，证明了血浆特定脂肪酸与终末期肝病结局之间的关联。
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