Gong Hongyang, Jiang Jiecheng, Choi Seok, Huang Shaoqun
Department of Oncology Surgery, Fuzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Department of Physiology, College of Medicine, Chosun University, Gwangju, Republic of Korea.
Front Nutr. 2024 Nov 20;11:1459117. doi: 10.3389/fnut.2024.1459117. eCollection 2024.
While prior research has established a correlation between dietary choline intake and bone density in the elderly, the relationship in adolescents remains ambiguous. This study seeks to examine the association between dietary choline intake and bone density in American adolescents.
Data from the National Health and Nutrition Examination Survey (NHANES) for 2005 to 2018 were used in this study, encompassing participants aged 12-19 years. The relationship between dietary choline intake and bone density was assessed using multivariate linear regression models and restricted cubic spline (RCS) models. Subgroup analyses were also performed to investigate differences across various subgroups.
3,800 participants with an average age of 15 years were included in this study. After adjusting for relevant confounding factors, a positive correlation was observed between dietary choline intake and total bone density in adolescents (95% CI: 0.03-0.17, = 0.010). Gender-specific analysis indicated a significant positive correlation between dietary choline intake and total bone density in males (95% CI: 0.07-0.23, < 0.001), while no significant correlation was found in females (95% CI: -0.19 to 0.09, = 0.500). The stratified analysis revealed that the positive association was more pronounced in males and non-Hispanic whites (interaction < 0.05). The restricted cubic spline model demonstrated a linear positive correlation between dietary choline intake and total bone density.
This study demonstrates that dietary choline intake levels are positively correlated with bone density in adolescents, with this association being specific to males.
虽然先前的研究已经证实老年人的膳食胆碱摄入量与骨密度之间存在关联，但青少年中的这种关系仍不明确。本研究旨在探讨美国青少年膳食胆碱摄入量与骨密度之间的关联。
本研究使用了2005年至2018年美国国家健康与营养检查调查（NHANES）的数据，涵盖12 - 19岁的参与者。使用多元线性回归模型和受限立方样条（RCS）模型评估膳食胆碱摄入量与骨密度之间的关系。还进行了亚组分析以调查不同亚组之间的差异。
本研究纳入了3800名平均年龄为15岁的参与者。在调整相关混杂因素后，观察到青少年膳食胆碱摄入量与总骨密度之间存在正相关（95%CI：0.03 - 0.17，P = 0.010）。按性别分析表明，男性膳食胆碱摄入量与总骨密度之间存在显著正相关（95%CI：0.07 - 0.23，P < 0.001），而女性未发现显著相关性（95%CI： - 0.19至0.09，P = 0.500）。分层分析显示，这种正相关在男性和非西班牙裔白人中更为明显（交互作用P < 0.05）。受限立方样条模型表明膳食胆碱摄入量与总骨密度之间存在线性正相关。
本研究表明，青少年膳食胆碱摄入量水平与骨密度呈正相关，且这种关联在男性中具有特异性。
