• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

犬类定制3D打印鼻咽支架：一项尸体初步研究。

Patient-specific 3D-printed nasopharyngeal stents in dogs: a cadaveric pilot study.

作者信息

Sutter Craig, Hardy Brian, Lucero Steven, Johnson Lynelle, Culp William

机构信息

Veterinary Medical Teaching Hospital, University of California, Davis, Davis, CA, United States.

Department of Medicine and Epidemiology, University of California, Davis, Davis, CA, United States.

出版信息

Front Vet Sci. 2024 Nov 20;11:1461657. doi: 10.3389/fvets.2024.1461657. eCollection 2024.

DOI:10.3389/fvets.2024.1461657
PMID:39634762
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11615054/
Abstract

BACKGROUND

Currently available treatment options for nasopharyngeal stenosis and imperforate nasopharynx in dogs and cats are fraught with complications and failures.

OBJECTIVE

To develop patient-specific nasopharyngeal stents using 3D-printed molds and to assess placement and fit of stents within the nasopharynx.

ANIMALS

Six canine cadavers.

METHODS

Patient-specific nasopharyngeal silicone stents were generated using 3D-printed molds based on CT scans. A placement protocol was developed. Post-placement, goodness of fit within the nasopharynx was evaluated and compared to currently used methods. Mechanical properties of silicone stents were compared to catheter-based and nitinol stents.

RESULTS

Development and placement of stents was successful in all six cadavers. Silicone stents offered stiffness (force required for compression, N) and post-load deformation comparable to nitinol stents (1.8-6.2 vs. 1.2-3.3 N and 0.02-0.08 vs. 0.01-0.14 mm, respectively). Patient-specific stents offered superior goodness of fit in the nasopharynx (81-90%) compared to bilateral red rubber catheters (16.2-33.8%).

CONCLUSION

Development and placement of patient-specific stents using 3D printed molds was successful in all six cadavers. The novel stents exhibited similar mechanical properties and superior goodness of fit compared to commercially available stents, potentially offering a better alternative to commercially available stents. Further investigation is needed in animals with nasopharyngeal stenosis to determine efficacy and to assess utility in live patients.

摘要

背景

目前用于犬猫鼻咽狭窄和鼻咽闭锁的治疗方法充满了并发症和失败案例。

目的

使用3D打印模具制作针对特定患者的鼻咽支架，并评估支架在鼻咽部的放置和适配情况。

动物

六只犬类尸体。

方法

基于CT扫描，使用3D打印模具制作针对特定患者的鼻咽硅胶支架。制定了放置方案。放置后，评估鼻咽部的适配情况，并与目前使用的方法进行比较。将硅胶支架的力学性能与导管型和镍钛合金支架进行比较。

结果

所有六具尸体的支架制作和放置均成功。硅胶支架的硬度（压缩所需力，N）和加载后变形与镍钛合金支架相当（分别为1.8 - 6.2对1.2 - 3.3 N以及0.02 - 0.08对0.01 - 0.14 mm）。与双侧红色橡胶导管（16.2 - 33.8%）相比，针对特定患者的支架在鼻咽部的适配性更佳（81 - 90%）。

结论

使用3D打印模具制作并放置针对特定患者的支架在所有六具尸体上均成功。与市售支架相比，新型支架具有相似的力学性能和更佳的适配性，可能为市售支架提供更好的替代方案。需要对患有鼻咽狭窄的动物进行进一步研究，以确定疗效并评估在活体患者中的实用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/11615054/27f69c4290e4/fvets-11-1461657-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/11615054/28618d926b0a/fvets-11-1461657-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/11615054/6b4f62279c8e/fvets-11-1461657-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/11615054/71f0a72f7b9e/fvets-11-1461657-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/11615054/c8c0f550b770/fvets-11-1461657-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/11615054/374154bdc7a7/fvets-11-1461657-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/11615054/9088a11d397f/fvets-11-1461657-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/11615054/f7f75a09243e/fvets-11-1461657-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/11615054/a48f5a74f7ed/fvets-11-1461657-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/11615054/c7c635c7b802/fvets-11-1461657-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/11615054/bcf6e7e896e1/fvets-11-1461657-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/11615054/b5f0a84669c3/fvets-11-1461657-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/11615054/62a819108a86/fvets-11-1461657-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/11615054/27f69c4290e4/fvets-11-1461657-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/11615054/28618d926b0a/fvets-11-1461657-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/11615054/6b4f62279c8e/fvets-11-1461657-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/11615054/71f0a72f7b9e/fvets-11-1461657-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/11615054/c8c0f550b770/fvets-11-1461657-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/11615054/374154bdc7a7/fvets-11-1461657-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/11615054/9088a11d397f/fvets-11-1461657-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/11615054/f7f75a09243e/fvets-11-1461657-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/11615054/a48f5a74f7ed/fvets-11-1461657-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/11615054/c7c635c7b802/fvets-11-1461657-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/11615054/bcf6e7e896e1/fvets-11-1461657-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/11615054/b5f0a84669c3/fvets-11-1461657-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/11615054/62a819108a86/fvets-11-1461657-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/11615054/27f69c4290e4/fvets-11-1461657-g013.jpg

相似文献

1
Patient-specific 3D-printed nasopharyngeal stents in dogs: a cadaveric pilot study.犬类定制3D打印鼻咽支架：一项尸体初步研究。
Front Vet Sci. 2024 Nov 20;11:1461657. doi: 10.3389/fvets.2024.1461657. eCollection 2024.
2
Interventional treatment of benign nasopharyngeal stenosis and imperforate nasopharynx in dogs and cats: 46 cases (2005-2013).犬猫良性鼻咽狭窄和鼻咽闭锁的介入治疗：46例（2005 - 2013年）
J Am Vet Med Assoc. 2018 Nov 15;253(10):1300-1308. doi: 10.2460/javma.253.10.1300.
3
Design of a nasopharyngeal tamponade device in canine cadavers.犬类尸体鼻咽填塞装置的设计
J Vet Emerg Crit Care (San Antonio). 2024 Nov-Dec;34(6):600-605. doi: 10.1111/vec.13427. Epub 2024 Nov 21.
4
Treatment of mixed and refractory post-tuberculosis tracheobronchial stenosis with L-shaped silicone stents: case series and a literature review.L 形硅酮支架治疗混合性和难治性肺结核性气管支气管狭窄：病例系列及文献复习。
Ther Adv Respir Dis. 2024 Jan-Dec;18:17534666241254901. doi: 10.1177/17534666241254901.
5
Use of a balloon-expandable metallic stent for treatment of nasopharyngeal stenosis in dogs and cats: six cases (2005-2007).使用球囊扩张金属支架治疗犬猫鼻咽狭窄：6例（2005 - 2007年）
J Am Vet Med Assoc. 2008 Nov 1;233(9):1432-40. doi: 10.2460/javma.233.9.1432.
6
Fracture of self-expanding nitinol stents stressed in vitro under simulated intravascular conditions.自膨式镍钛诺支架在模拟血管内条件下体外受力时的骨折。
J Vasc Surg. 2008 Aug;48(2):435-40. doi: 10.1016/j.jvs.2008.02.029. Epub 2008 May 16.
7
3D-printed flexible polymer stents for potential applications in inoperable esophageal malignancies.3D 打印的柔性聚合物支架，可潜在应用于无法手术的食管恶性肿瘤。
Acta Biomater. 2019 Jan 1;83:119-129. doi: 10.1016/j.actbio.2018.10.035. Epub 2018 Oct 24.
8
Treatment of acquired nasopharyngeal stenosis using a removable silicone stent.使用可移除硅胶支架治疗获得性鼻咽狭窄。
J Feline Med Surg. 2015 Feb;17(2):117-24. doi: 10.1177/1098612X14533692. Epub 2014 May 12.
9
Comparison of Flow Characteristics of Novel Three-Dimensional Printed Ureteral Stents Versus Standard Ureteral Stents in a Porcine Model.新型三维打印输尿管支架与标准输尿管支架在猪模型中的血流特性比较。
J Endourol. 2015 Sep;29(9):1065-9. doi: 10.1089/end.2014.0716. Epub 2015 Jul 21.
10
CFD based analysis of 3D printed nasopharyngeal swabs for COVID-19 diagnostics.基于 CFD 的用于 COVID-19 诊断的 3D 打印鼻咽拭子分析。
Comput Methods Programs Biomed. 2022 Aug;223:106977. doi: 10.1016/j.cmpb.2022.106977. Epub 2022 Jun 27.

本文引用的文献

1
Determination of patient-specific airway stent fit using novel 3D reconstruction measurement techniques: a 4-year follow-up of a patient.使用新型三维重建测量技术确定患者特定气道支架适配度：一名患者的 4 年随访结果。
Ther Adv Respir Dis. 2023 Jan-Dec;17:17534666221137999. doi: 10.1177/17534666221137999.
2
Virtual surgical planning and 3D printing: Methodology and applications in veterinary oromaxillofacial surgery.虚拟手术规划与3D打印：在兽医口腔颌面外科中的方法与应用
Front Vet Sci. 2022 Oct 21;9:971318. doi: 10.3389/fvets.2022.971318. eCollection 2022.
3
3D printing for surgical planning of canine oral and maxillofacial surgeries.
用于犬类口腔颌面外科手术规划的3D打印技术
3D Print Med. 2022 Jun 9;8(1):17. doi: 10.1186/s41205-022-00142-y.
4
Virtual Surgical Planning and 3D Printing in Veterinary Dentistry and Oromaxillofacial Surgery.兽医牙科和口腔颌面外科学中的虚拟手术规划和 3D 打印。
Vet Clin North Am Small Anim Pract. 2022 Jan;52(1):221-234. doi: 10.1016/j.cvsm.2021.09.009.
5
Treatment of airway stenosis with a customized bronchial stent using a three-dimensional printer and flexible filaments.使用三维打印机和柔性细丝定制支气管支架治疗气道狭窄
Respirol Case Rep. 2019 Sep 25;7(9):e00491. doi: 10.1002/rcr2.491. eCollection 2019 Dec.
6
Accuracy of external measurements of 3-dimensional (3D) printed biomodels of the canine radius used in an in-hospital setting.在医院环境中使用的犬桡骨三维（3D）打印生物模型外部测量的准确性。
Can J Vet Res. 2019 Jul;83(3):181-186.
7
Accuracy and precision of measurements performed on three-dimensional printed pelvises when compared to computed tomography measurements.与计算机断层扫描测量结果相比，对三维打印骨盆进行测量的准确性和精密度。
J Vet Sci. 2019 May;20(3):e22. doi: 10.4142/jvs.2019.20.e22.
8
Interventional treatment of benign nasopharyngeal stenosis and imperforate nasopharynx in dogs and cats: 46 cases (2005-2013).犬猫良性鼻咽狭窄和鼻咽闭锁的介入治疗：46例（2005 - 2013年）
J Am Vet Med Assoc. 2018 Nov 15;253(10):1300-1308. doi: 10.2460/javma.253.10.1300.
9
Application of 3D Printing for Patient-Specific Silicone Stents: 1-Year Follow-Up on 2 Patients.3D 打印在个体化硅胶支架中的应用：2 例患者 1 年随访结果。
Respiration. 2018;96(5):488-494. doi: 10.1159/000489669. Epub 2018 Sep 13.
10
Patient-specific, 3-dimensionally engineered silicone Y-stents in tracheobronchomalacia: Clinical experience with a novel type of airway stent.针对气管支气管软化症的个性化三维工程硅胶Y形支架：一种新型气道支架的临床经验
J Thorac Cardiovasc Surg. 2018 Nov;156(5):2019-2021. doi: 10.1016/j.jtcvs.2018.06.049. Epub 2018 Jul 18.