Furqan Saira, Ahmed Asma, Batool Sumera, Islam Najmul
Saira Furqan, MBBS, FCPS (Medicine), FCPS (Endocrinology) Assistant Professor, Endocrinology Diabetes and Metabolism, Department of Medicine, The Aga Khan University Hospital, Karachi, Pakistan.
Asma Ahmed, MBBS, MRCP, Certificate in Diabetes & Endocrinology Assistant Professor, Endocrinology Diabetes and Metabolism, Department of Medicine, The Aga Khan University Hospital, Karachi, Pakistan.
Pak J Med Sci. 2024 Dec;40(11):2631-2635. doi: 10.12669/pjms.40.11.7036.
Although differentiated thyroid cancers have a good prognosis overall, their incidence is on the rise with extremely limited data available in our region. The objective was to describe the outcomes of differentiated thyroid carcinoma in a tertiary care hospital.
This was a retrospective study conducted at Aga Khan University Hospital. The data was collected by reviewing the charts and reports of patients (1999-2011) diagnosed with differentiated thyroid cancer. Information regarding the demographic status, type of differentiated thyroid cancer, stage at the time of presentation, and the outcome was noted. The study endpoints were the disease cure, persistence, and recurrence.
Most of the patients were diagnosed with papillary carcinoma stage-I (49.0%) having a cure rate of 52.94%, a persistence rate of 28.43%, and a recurrence rate of 18.62%. A 33.3% of patients with follicular carcinoma at stage-4 had zero cure rate, the persistence rate was 25% and the recurrence rate was also 25%. In patients with hurthle cell variant of follicular carcinoma; the majority (60.0%) were diagnosed at stage-I having a cure rate of 80%. The persistence rate was 0%, and the recurrence rate was 20%.
This study highlights the low cure rate while describing the high rate of disease persistence and recurrence. This can be due to delays related to the diagnosis and scarcity of proper treatment. Recognition of this emergent disease is vital so that curative methods prescribed at proper time can diminish the morbidity and mortality linked with this treatable cancer.
尽管分化型甲状腺癌总体预后良好，但在我们这个地区其发病率呈上升趋势，而相关数据极为有限。本研究旨在描述一家三级医院中分化型甲状腺癌的治疗结果。
这是一项在阿迦汗大学医院开展的回顾性研究。通过查阅1999年至2011年期间诊断为分化型甲状腺癌患者的病历和报告来收集数据。记录有关人口统计学状况、分化型甲状腺癌的类型、就诊时的分期以及治疗结果等信息。研究终点为疾病治愈、持续存在和复发情况。
大多数患者被诊断为I期乳头状癌（49.0%），治愈率为52.94%，持续存在率为28.43%，复发率为18.62%。33.3%的IV期滤泡状癌患者治愈率为零，持续存在率为25%，复发率也为25%。在滤泡状癌的赫氏细胞变异型患者中，大多数（60.0%）被诊断为I期，治愈率为80%。持续存在率为0%，复发率为20%。
本研究在描述疾病高持续存在率和复发率的同时，凸显了低治愈率。这可能是由于诊断延误和缺乏恰当治疗所致。认识到这种新出现的疾病至关重要，以便在恰当时间采用治愈性方法可降低与这种可治疗癌症相关的发病率和死亡率。
