Carosso A, Ruffino C, Bugiani M
Ann Allergy. 1986 Apr;56(4):300-3.
The purpose of this paper is to examine whether exposure to antigens in the early months of life can increase or decrease subsequent sensitization. With this aim in mind, 304 subjects undergoing hyposensitization were randomly selected in an out-patient study: 207 of them had pollenosis (seasonal asthma, rhinitis, and positive skin tests to grass pollen) and 97, house dust respiratory allergy (perennial asthma and rhinitis with positive skin tests to house dust mites). The results of the study show a statistically significant association (P less than .005) between birth in grass pollen season and pollenosis. The region of birth (north or south Italy) appeared to be a "deterministic" effect modificator; the odds ratio due to the birth season was 5.099 in the northern and 0.997 in the southern Italian regions. The main effect of the region of birth was not significant, neither was sex, age, and the region of birth of the parents (main, polinomial and interaction effects). It is likely that there is a real relationship between the month of birth of atopic subjects and the prevalence of the pollenosis. The precise reason(s) of the different degrees of association between month of birth and pollenosis in subjects born in northern and southern Italy is not clear.
本文的目的是研究生命早期几个月接触抗原是否会增加或降低随后的致敏作用。出于这一目的，在一项门诊研究中随机选择了304名接受减敏治疗的受试者：其中207人患有花粉症（季节性哮喘、鼻炎，对草花粉皮肤试验呈阳性），97人患有屋尘呼吸道过敏（常年性哮喘和鼻炎，对屋尘螨皮肤试验呈阳性）。研究结果显示，在草花粉季节出生与花粉症之间存在统计学上的显著关联（P小于0.005）。出生地区（意大利北部或南部）似乎是一个“决定性”效应修饰因素；出生季节导致的优势比在意大利北部地区为5.099，在意大利南部地区为0.997。出生地区的主要影响不显著，性别、年龄以及父母的出生地区（主要、多项式和交互作用）也不显著。特应性受试者的出生月份与花粉症患病率之间可能存在实际关联。出生在意大利北部和南部的受试者，其出生月份与花粉症之间关联程度不同的确切原因尚不清楚。
