Mullarkey M F, Webb D R, Pardee N E
Ann Allergy. 1986 Apr;56(4):347-50.
A 63-year-old woman with refractory psoriatic arthritis and asthma, requiring intermittent steroid therapy, was treated with methotrexate (MTX). Her arthritis responded rapidly and it was noted that her asthma required no further steroid therapy. Six patients with established steroid-dependent asthma were then treated with 7.5 to 15.0 mg of MTX per week, after protocols used to treat psoriasis and rheumatoid arthritis. Five patients reduced their steroid usage while on MTX. Side effects were minimal while taking MTX. It was concluded that MTX may have a role in reducing cortisone requirements in steroid-dependent asthma.
一名63岁患有难治性银屑病关节炎和哮喘且需要间歇性类固醇治疗的女性，接受了甲氨蝶呤（MTX）治疗。她的关节炎迅速得到缓解，并且注意到她的哮喘不再需要进一步的类固醇治疗。随后，按照用于治疗银屑病和类风湿性关节炎的方案，对6名确诊为类固醇依赖型哮喘的患者每周使用7.5至15.0毫克的甲氨蝶呤进行治疗。5名患者在服用甲氨蝶呤期间减少了类固醇的用量。服用甲氨蝶呤时副作用极小。得出的结论是，甲氨蝶呤可能在降低类固醇依赖型哮喘患者对可的松的需求方面发挥作用。
