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人乳中内源性病毒颗粒微小RNA与寡糖浓度之间的关联。

Associations between human milk EV-miRNAs and oligosaccharide concentrations in human milk.

作者信息

Holzhausen Elizabeth A, Patterson William B, Wong Benjamin H, Kim Sewan, Kupsco Allison, Howe Caitlin G, Bode Lars, Goran Michael I, Alderete Tanya L

机构信息

Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States.

Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.

出版信息

Front Immunol. 2024 Nov 20;15:1463463. doi: 10.3389/fimmu.2024.1463463. eCollection 2024.

DOI:10.3389/fimmu.2024.1463463
PMID:39635519
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11614774/
Abstract

INTRODUCTION

Human milk contains human milk oligosaccharides (HMOs) and microRNAs (miRNAs), which are key bioactive components. HMOs are indigestible carbohydrates that impact infant growth and development. miRNAs are small, non-coding RNAs that regulate post-transcriptional gene expression. miRNAs are abundant in human milk and can be contained in extracellular vesicles (EVs). There is evidence that miRNAs are synthesized in the mammary epithelium and may influence mammary gland development and milk synthesis. However, the relationships between miRNAs and HMOs have yet to be fully characterized.

METHODS

This study examined the associations between 210 human milk EV-miRNAs and 19 HMOs in a cohort of 98 Latina mothers. HMO measures included summary measures and concentrations of 19 HMOs. Relationships between EV-miRNAs and HMOs were examined using principal components analysis and associations between individual EV-miRNAs and HMOs were assessed.

RESULTS

Overall patterns of EV-miRNA levels, summarized using principal components, were associated with HMO summary measures and concentrations. Levels of individual EV-miRNAs were associated with HMO summary measures and individual concentrations of 2'FL, 3FL, 3'SL, 6'SL, FLNH, LNFP I, and LNH.

DISCUSSION

Results from this study suggest that human milk EV-miRNAs are associated with the concentration of HMOs, which may have important effects on infant growth and development.

摘要

引言

人乳中含有母乳低聚糖（HMOs）和微小RNA（miRNAs），它们是关键的生物活性成分。HMOs是不可消化的碳水化合物，会影响婴儿的生长发育。miRNAs是小的非编码RNA，可调节转录后基因表达。miRNAs在人乳中含量丰富，且可存在于细胞外囊泡（EVs）中。有证据表明，miRNAs在乳腺上皮细胞中合成，可能影响乳腺发育和乳汁合成。然而，miRNAs与HMOs之间的关系尚未完全明确。

方法

本研究在98名拉丁裔母亲的队列中，检测了210种人乳EV-miRNAs与19种HMOs之间的关联。HMO测量包括19种HMOs的汇总测量值和浓度。使用主成分分析研究EV-miRNAs与HMOs之间的关系，并评估单个EV-miRNAs与HMOs之间的关联。

结果

使用主成分汇总的EV-miRNA水平总体模式与HMO汇总测量值和浓度相关。单个EV-miRNAs的水平与HMO汇总测量值以及2'FL、3FL、3'SL、6'SL、FLNH、LNFP I和LNH的个体浓度相关。

讨论

本研究结果表明，人乳EV-miRNAs与HMOs的浓度相关，这可能对婴儿的生长发育产生重要影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f7e/11614774/4757f2ce27e4/fimmu-15-1463463-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f7e/11614774/4757f2ce27e4/fimmu-15-1463463-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f7e/11614774/4757f2ce27e4/fimmu-15-1463463-g001.jpg

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本文引用的文献

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Human milk EV-miRNAs: a novel biomarker for air pollution exposure during pregnancy.人乳细胞外囊泡微小RNA：孕期空气污染暴露的新型生物标志物
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Influence of technical and maternal-infant factors on the measurement and expression of extracellular miRNA in human milk.
技术和母婴因素对人乳中外泌体 miRNA 测量和表达的影响。
Front Immunol. 2023 Jul 10;14:1151870. doi: 10.3389/fimmu.2023.1151870. eCollection 2023.
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DIANA-miRPath v4.0: expanding target-based miRNA functional analysis in cell-type and tissue contexts.DIANA-miRPath v4.0：在细胞类型和组织背景下扩展基于靶标的 miRNA 功能分析。
Nucleic Acids Res. 2023 Jul 5;51(W1):W154-W159. doi: 10.1093/nar/gkad431.
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