物理治疗后4个月居家动态站立方案可维持帕金森病患者物理治疗效果并改善其活动能力、平衡信心、跌倒恐惧及生活质量：一项随机对照、检查者盲法的可行性临床试验
Post-Physical Therapy 4-Month In-Home Dynamic Standing Protocol Maintains Physical Therapy Gains and Improves Mobility, Balance Confidence, Fear of Falling and Quality of Life in Parkinson's Disease: A Randomized Controlled Examiner-Blinded Feasibility Clinical Trial.
作者信息
Boas Miriam van Emde, Pongmala Chatkaew, Biddix Abigail M, Griggs Alexis, Luker Austin T, Carli Giulia, Marusic Uros, Bohnen Nicolaas I
机构信息
Functional Neuroimaging, Cognitive & Mobility Laboratory, University of M ichigan, Ann Arbor, MI, USA.
Morris K. Udall Center of Excellence in Parkinson's Disease Research, University of Michigan, Ann Arbor, MI, USA.
出版信息
J Frailty Sarcopenia Falls. 2024 Dec 1;9(4):267-280. doi: 10.22540/JFSF-09-267. eCollection 2024 Dec.
OBJECTIVE
Parkinson's patients will experience mobility disturbances with disease progression. Beneficial effects of physical therapy are short-lasting. Novel interventions are needed to maintain these benefits.
METHODS
Fourteen Parkinson's patients (71±4.08 years) participated in a randomized controlled examiner-blinded feasibility clinical trial. After 12 physical therapy sessions, the intervention group received a height-adjustable desk that facilitates stepping while standing, for 4 months. Explorative outcome measures included MDS-UPDRS II, III, TUG, 8.5m walking test, PDQ-39, sABC, sFES, DEXA scans, and lower extremity strength.
RESULTS
Post-physical-therapy, everyone significantly improved on the MDS-UPDRS II, III, TUG, and 8.5m walking test, and PDQ-39. (p<0.05) After 4 months, the control group regressed towards pre-physical-therapy values. In the intervention group, sedentary behavior decreased beyond desk use, indicating a carry-over effect. MDS-UPDRS II, PDQ-39, sFES, sABC, TUG, 8.5m walking test, activity time, sitting time, hip strength all improved with clinically relevant effect sizes.
CONCLUSION
Post-physical therapy in-home reduction of sedentary behavior was associated with maintenance of physical benefits and additional improvements in mobility, activity time, balance and quality of life.
目的
帕金森病患者会随着疾病进展出现运动障碍。物理治疗的有益效果持续时间较短。需要新的干预措施来维持这些益处。
方法
14名帕金森病患者（71±4.08岁）参与了一项随机对照、检查者盲法的可行性临床试验。在进行12次物理治疗后，干预组接受了一张可调节高度的桌子，便于站立时踏步，为期4个月。探索性结局指标包括MDS-UPDRS II、III、TUG、8.5米步行测试、PDQ-39、sABC、sFES、DEXA扫描以及下肢力量。
结果
物理治疗后，所有人在MDS-UPDRS II、III、TUG和8.5米步行测试以及PDQ-39方面均有显著改善。（p<0.05）4个月后，对照组恢复到物理治疗前的值。在干预组中，久坐行为减少，超出了使用桌子的影响，表明存在延续效应。MDS-UPDRS II、PDQ-39、sFES、sABC、TUG、8.5米步行测试、活动时间、久坐时间、髋部力量均有改善，且具有临床相关效应量。
结论
物理治疗后在家中减少久坐行为与维持身体益处以及在运动能力、活动时间、平衡和生活质量方面的额外改善相关。
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