Boas Miriam van Emde, Pongmala Chatkaew, Biddix Abigail M, Griggs Alexis, Luker Austin T, Carli Giulia, Marusic Uros, Bohnen Nicolaas I
Functional Neuroimaging, Cognitive & Mobility Laboratory, University of M ichigan, Ann Arbor, MI, USA.
Morris K. Udall Center of Excellence in Parkinson's Disease Research, University of Michigan, Ann Arbor, MI, USA.
J Frailty Sarcopenia Falls. 2024 Dec 1;9(4):267-280. doi: 10.22540/JFSF-09-267. eCollection 2024 Dec.
Parkinson's patients will experience mobility disturbances with disease progression. Beneficial effects of physical therapy are short-lasting. Novel interventions are needed to maintain these benefits.
Fourteen Parkinson's patients (71±4.08 years) participated in a randomized controlled examiner-blinded feasibility clinical trial. After 12 physical therapy sessions, the intervention group received a height-adjustable desk that facilitates stepping while standing, for 4 months. Explorative outcome measures included MDS-UPDRS II, III, TUG, 8.5m walking test, PDQ-39, sABC, sFES, DEXA scans, and lower extremity strength.
Post-physical-therapy, everyone significantly improved on the MDS-UPDRS II, III, TUG, and 8.5m walking test, and PDQ-39. (p<0.05) After 4 months, the control group regressed towards pre-physical-therapy values. In the intervention group, sedentary behavior decreased beyond desk use, indicating a carry-over effect. MDS-UPDRS II, PDQ-39, sFES, sABC, TUG, 8.5m walking test, activity time, sitting time, hip strength all improved with clinically relevant effect sizes.
Post-physical therapy in-home reduction of sedentary behavior was associated with maintenance of physical benefits and additional improvements in mobility, activity time, balance and quality of life.
帕金森病患者会随着疾病进展出现运动障碍。物理治疗的有益效果持续时间较短。需要新的干预措施来维持这些益处。
14名帕金森病患者（71±4.08岁）参与了一项随机对照、检查者盲法的可行性临床试验。在进行12次物理治疗后，干预组接受了一张可调节高度的桌子，便于站立时踏步，为期4个月。探索性结局指标包括MDS-UPDRS II、III、TUG、8.5米步行测试、PDQ-39、sABC、sFES、DEXA扫描以及下肢力量。
物理治疗后，所有人在MDS-UPDRS II、III、TUG和8.5米步行测试以及PDQ-39方面均有显著改善。（p<0.05）4个月后，对照组恢复到物理治疗前的值。在干预组中，久坐行为减少，超出了使用桌子的影响，表明存在延续效应。MDS-UPDRS II、PDQ-39、sFES、sABC、TUG、8.5米步行测试、活动时间、久坐时间、髋部力量均有改善，且具有临床相关效应量。
物理治疗后在家中减少久坐行为与维持身体益处以及在运动能力、活动时间、平衡和生活质量方面的额外改善相关。
