Cai Yingying, Feng Fei, Wei Qianqian, Jiang Zheng, Ou Ruwei, Shang Huifang
Laboratory of Neurodegenerative Disorders, Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Department of Geriatrics, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
Front Neurol. 2021 Mar 5;12:598035. doi: 10.3389/fneur.2021.598035. eCollection 2021.
Parkinson's disease (PD) and sarcopenia are two common diseases in aging people. To date, the prevalence of sarcopenia in PD patients and the relationship between clinical features and sarcopenia in PD patients are not clear. The aim of the study was to (1) assess the prevalence of sarcopenia in PD patients and (2) reveal the clinical features between PD patients with and without sarcopenia. A systematic review was carried out through screening PubMed, EMBASE, and Cochrane database in May 2020. All study designs (case-control, cohort, and cross-sectional studies) were eligible for meta-analysis. Data of patients' characteristics, sarcopenia criteria, sarcopenia prevalence, and sarcopenia measures were retrieved. The primary outcome was estimated prevalence of sarcopenia by a pooled prevalence (%) and its 95% confidence interval (CI), using a random-effects model. The secondary outcome was the differences in clinical features between PD patients with and without sarcopenia by meta-analysis. Included articles were assessed for risk of bias. Potential sources of variation were investigated by using subgroup analyses and meta-regression. Ten studies were included in the review. Among them, nine were cross-sectional studies, and one was a prospective cohort study. Age of participants with PD in the studies ranged from 51.1 to 80.7 years. The estimated prevalence of sarcopenia ranged from 6 to 55.5%. The random-effects pooled prevalence was 29% (95% CIs: 0.18-0.40). When only studies at low risk of bias were considered, pooled prevalence decreased to 17% (95% CIs: 0.02-0.33), with still high heterogeneity. The incidence of falls in PD patients with sarcopenia was higher than that in PD patients without sarcopenia. There was no difference in sex ratio between PD patients with and without sarcopenia. Sarcopenia seems to be common in patients with PD. Early assessment of sarcopenia should be implemented in PD to avoid fall and disability.
帕金森病（PD）和肌肉减少症是老年人中的两种常见疾病。迄今为止，PD患者中肌肉减少症的患病率以及PD患者临床特征与肌肉减少症之间的关系尚不清楚。本研究的目的是：（1）评估PD患者中肌肉减少症的患病率；（2）揭示有和无肌肉减少症的PD患者之间的临床特征。2020年5月通过筛选PubMed、EMBASE和Cochrane数据库进行了一项系统评价。所有研究设计（病例对照研究、队列研究和横断面研究）均符合荟萃分析的条件。检索了患者特征、肌肉减少症标准、肌肉减少症患病率和肌肉减少症测量的数据。主要结局是使用随机效应模型通过合并患病率（%）及其95%置信区间（CI）估计肌肉减少症的患病率。次要结局是通过荟萃分析比较有和无肌肉减少症的PD患者临床特征的差异。对纳入的文章进行偏倚风险评估。通过亚组分析和荟萃回归研究潜在的变异来源。本评价纳入了10项研究。其中，9项为横断面研究，1项为前瞻性队列研究。研究中PD患者的年龄范围为51.1至80.7岁。肌肉减少症的估计患病率范围为6%至55.5%。随机效应合并患病率为29%（95%CI：0.18 - 0.40）。当仅考虑低偏倚风险的研究时，合并患病率降至17%（95%CI：0.02 - 0.33），异质性仍然很高。有肌肉减少症的PD患者跌倒发生率高于无肌肉减少症的PD患者。有和无肌肉减少症的PD患者之间的性别比例没有差异。肌肉减少症在PD患者中似乎很常见。应在PD患者中尽早进行肌肉减少症评估，以避免跌倒和残疾。
