Zheng Zequan, Chen Fajun, Qin Lulu, Lu Aili, Xu Haoyou, Zhao Min, Zhao Yuanqi
Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, China.
Guangzhou University of Traditional Chinese Medicine, Guangzhou, China.
Front Med (Lausanne). 2024 Nov 20;11:1431225. doi: 10.3389/fmed.2024.1431225. eCollection 2024.
is a kind of brain-eating amoeba leading to granulomatous amoebic encephalitis (GAE) with a high mortality rate and limited effective treatment options. Its underlying pathological mechanisms are still poorly understood. Here, we presented a 58-year-old man with meningoencephalitis, who died 33 days after onset. In this unique case, we introduced the use of ventriculoscopy in the treatment of meningoencephalitis. Through ventriculoscopy, we observed that the inflammatory response triggered by the disease was diffuse and extensive throughout the ventricles and meninges, not limited to the region of parasite invasion. Furthermore, under the precise guidance of ventriculoscopy, we implemented drug lavage therapy and intraventricular drainage, which, to a certain extent, managed to mitigate the progression of hydrocephalus and intracranial hypertension. Despite the unfortunate outcome of the patient's death due to brainstem hemorrhage, we reiterate the crucial role that surgical intervention plays in both diagnosing and managing amoebic encephalitis. This underscores the need for continued research and innovation in surgical techniques to enhance patient outcomes and combat this challenging neurological condition.
是一种导致肉芽肿性阿米巴脑炎（GAE）的噬脑变形虫，死亡率高且有效治疗选择有限。其潜在的病理机制仍知之甚少。在此，我们报告了一名58岁的脑膜脑炎男性患者，发病33天后死亡。在这个独特的病例中，我们介绍了脑室镜在脑膜脑炎治疗中的应用。通过脑室镜，我们观察到该疾病引发的炎症反应在整个脑室和脑膜中弥漫且广泛，不限于寄生虫侵袭区域。此外，在脑室镜的精确引导下，我们实施了药物灌洗治疗和脑室内引流，这在一定程度上设法减轻了脑积水和颅内高压的进展。尽管患者因脑干出血不幸死亡，但我们重申手术干预在阿米巴脑炎的诊断和管理中所起的关键作用。这凸显了在手术技术方面持续研究和创新以改善患者预后并对抗这种具有挑战性的神经系统疾病的必要性。
