Glaze M B, Turk M A
Am J Vet Res. 1986 Apr;47(4):913-8.
Radiofrequency hyperthermia was used to induce axial corneal lesions in the eyes of 10 dogs. Clinical observations were continued for up to 6 months, using biomicroscopy and indirect ophthalmoscopy. Eyes were harvested at intervals for light and electron microscopic evaluation. Clinical alterations included immediate corneal opacification and epithelial disruption at the site of electrode contact. Ulcerative keratitis persisted for 4 to 6 days, accompanied by anterior uveitis. Additional corneal changes included stromal thinning, edema, and vascularization. Final evaluation revealed negligible alterations in corneal contour or clarity 6 months after treatment. Microscopically, epithelial and superficial stromal necrosis preceded epithelial loss. Stromal alterations included edema (associated with focal endothelial detachments), vascularization, and inflammatory cell infiltration. Recovery was characterized by keratocytic hyperplasia and hypertrophy, epithelial proliferation, and stromal condensation.
采用射频热疗在10只犬的眼睛中诱导轴向角膜损伤。使用生物显微镜和间接检眼镜持续进行临床观察长达6个月。每隔一段时间摘取眼睛进行光镜和电镜评估。临床改变包括电极接触部位立即出现角膜混浊和上皮破坏。溃疡性角膜炎持续4至6天，伴有前葡萄膜炎。角膜的其他变化包括基质变薄、水肿和血管化。最终评估显示治疗6个月后角膜轮廓或清晰度的改变可忽略不计。显微镜下，上皮和浅层基质坏死先于上皮脱落。基质改变包括水肿（与局灶性内皮脱离有关）、血管化和炎性细胞浸润。恢复的特征为角膜细胞增生和肥大、上皮增殖以及基质浓缩。
