Barboza Eliane Porto, Panariello Beatriz
School of Dental Medicine, Lake Erie College of Osteopathic Medicine, 4800 Lakewood Ranch Blvd, Bradenton, FL, 34211, USA.
School of Dentistry, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil.
Clin Oral Investig. 2024 Dec 5;28(12):685. doi: 10.1007/s00784-024-06079-2.
This letter addresses the recent study by Braz et al. published in Clinical Oral Investigations in 2024 ( https://doi.org/10.1007/s00784-024-05763-7 ), which reported that intentionally exposed d-PTFE membranes modulate microbial colonization in alveolar ridge preservation (ARP) sites, creating a more homogeneous and anaerobic community on both the inner and outer surfaces of the membrane.
We argue that the study's methodology may have skewed the results, particularly the inclusion of both intact and damaged extraction sockets (with loss of the buccal wall) and the absence of bone grafting.
The absence of bone graft might have contributed to membrane dislodgement and increased microbial contamination rather than the membrane's inherent properties.
This critique is significant because it challenges the conclusion that the d-PTFE membrane itself is responsible for microbial colonization, highlighting the need to consider extrinsic factors and study design limitations.
Our discussion aims to enhance the understanding of microbial dynamics in ARP procedures and emphasizes the need for caution when interpreting the study's findings, given the context of established clinical practices and existing evidence.
本信函针对Braz等人于2024年发表在《临床口腔研究》（https://doi.org/10.1007/s00784-024-05763-7）上的最新研究。该研究报告称，故意暴露的d-PTFE膜可调节牙槽嵴保存（ARP）部位的微生物定植，在膜的内表面和外表面形成更均匀的厌氧群落。
我们认为该研究的方法可能使结果产生偏差，特别是纳入了完整和受损的拔牙窝（颊壁缺失）且未进行骨移植。
未进行骨移植可能导致了膜的移位和微生物污染增加，而非膜的固有特性。
这一批评很重要，因为它对d-PTFE膜本身导致微生物定植这一结论提出了挑战，强调了考虑外在因素和研究设计局限性的必要性。
我们的讨论旨在增进对ARP手术中微生物动态的理解，并强调鉴于既定临床实践和现有证据的背景，在解释该研究结果时需谨慎。
