Li Jiang-Hui, Yan Xiao-Ning, Fu Jia-Ying, Hu Hao-Yuan
The First Clinical Medical college, Shaanxi University of Chinese Medicine, Xianyang, China.
Department of Dermatology, Shaanxi Hospital of Traditional Chinese Medicine, Xi'an, China.
PLoS One. 2024 Dec 5;19(12):e0314964. doi: 10.1371/journal.pone.0314964. eCollection 2024.
Exposure to environmental pollutants is increasingly recognized as a risk factor for the development of psoriasis. Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the air and might induce reactions such as oxidative stress. Nevertheless, it is still unclear if PAHs have any influence on the prevalence of psoriasis over the entire population of the United States. The objective of this study was to assess the association between urine PAHs and psoriasis.
The research included 3,673 individuals aged 20 years or older who participated in the 2003-2006 and 2009-2012 National Health and Nutrition Examination Surveys (NHANES). We employed logistic regression models to evaluate the relationship between levels of urine PAH metabolites and psoriasis and smoothed curve fitting to illustrate the concentration-response relationship. Additionally, subgroup and interaction analyses were conducted to elucidate these associations. Furthermore, we employed weighted quartile sum (WQS) regressions to examine the distinct effects of individual and mixed urine PAH metabolites on psoriasis. However, it is important to note that the NHANES sample may be subject to selectivity and self-reporting bias, which may influence the data' generalisability.
We observed that the highest tertiles of 2-NAP and 2-FLU had a 63% (95% CI 1.02, 2.61) and 83% (95% CI 1.14, 2.96) higher odds of association with psoriasis prevalence, respectively. Meanwhile, tertile 2 and tertile 3 of 3-PHE were also significantly associated with psoriasis, with higher odds of 65% (95% CI 1.01, 2.69) and 14% (95% CI 1.17, 3.00), respectively. The subgroup analyses revealed a significant correlation between urine PAH metabolites and the odds of psoriasis in specific groups, including males, aged 40-60 years, with a BMI > 30, and those with hyperlipidemia. In the WQS model, a positive association was found between the combination of urine PAH metabolites and psoriasis (OR 1.43, 95% CI 1.11, 1.84), with 2-FLU being the most prevalent component across all mixtures (0.297).
Our findings indicate a significant association between urine PAH metabolites and the odds of psoriasis prevalence in adults. Among these metabolites, 2-FLU demonstrated the most prominent impact. Controlling PAH exposure, as an important strategy for minimizing exposure to environmental contaminants and lowering the risk of psoriasis, is critical for raising public knowledge about environmental health and preserving public health.
环境污染物暴露日益被视为银屑病发病的一个风险因素。多环芳烃（PAHs）在空气中普遍存在，可能引发诸如氧化应激等反应。然而，PAHs对美国全体人群中银屑病患病率是否有任何影响仍不清楚。本研究的目的是评估尿中PAHs与银屑病之间的关联。
该研究纳入了3673名年龄在20岁及以上、参加了2003 - 2006年和2009 - 2012年国家健康与营养检查调查（NHANES）的个体。我们采用逻辑回归模型来评估尿中PAH代谢物水平与银屑病之间的关系，并进行平滑曲线拟合以说明浓度 - 反应关系。此外，进行了亚组分析和交互作用分析以阐明这些关联。此外，我们采用加权四分位数和（WQS）回归来检验个体和混合尿中PAH代谢物对银屑病的不同影响。然而，需要注意的是，NHANES样本可能存在选择性和自我报告偏差，这可能会影响数据的普遍性。
我们观察到，2 - 萘酚（2 - NAP）和2 - 氟萘（2 - FLU）的最高三分位数与银屑病患病率的关联几率分别高出63%（95%CI 1.02，2.61）和83%（95%CI 1.14，2.96）。同时，3 - 苯并[a]芘（3 - PHE）的第二三分位数和第三三分位数也与银屑病显著相关，关联几率分别高出65%（95%CI 1.01，2.69）和14%（95%CI 1.17，3.00）。亚组分析显示，尿中PAH代谢物与特定组别的银屑病几率之间存在显著相关性，这些组别包括男性、年龄在40 - 60岁、BMI > 30以及患有高脂血症的人群。在WQS模型中，发现尿中PAH代谢物的组合与银屑病之间存在正相关（OR 1.43，95%CI 1.11，1.84），2 - FLU是所有混合物中最普遍的成分（0.297）。
我们的研究结果表明，尿中PAH代谢物与成人银屑病患病率几率之间存在显著关联。在这些代谢物中，2 - FLU表现出最显著的影响。控制PAH暴露作为减少环境污染物暴露和降低银屑病风险的一项重要策略，对于提高公众对环境卫生的认识和维护公众健康至关重要。
