Couwenbergs C, Knussmann R, Christiansen K
Ann Hum Biol. 1986 Jan-Feb;13(1):63-72. doi: 10.1080/03014468600008201.
Six blood samples were taken from each of 33 healthy young men during the course of 2 weeks. From these, the testosterone, dihydrotestosterone, and oestradiol levels were determined. In addition, free testosterone was measured using saliva samples obtained from 23 of the subjects. Both coefficients of variation and variance analyses showed that the inter-individual variability is greater than the intra-individual for all of the hormones. No influence of the day of the week could be ascertained. However, it was discovered that the serum hormone levels dropped with age (weakly significant for oestradiol, insignificant for the androgens) in spite of the subjects being in or near their third decade. The pooled intra-individual correlations between the hormones all fell within the moderate to middle-high positive domain, whereas the inter-individual correlations ranged between highly positive (testosterone to dihydrotestosterone), middle highly positive (free testosterone to total testosterone), and slightly negative (free testosterone to oestradiol).
在两周内，从33名健康年轻男性中每人采集6份血样。由此测定了睾酮、双氢睾酮和雌二醇水平。此外，使用从23名受试者获得的唾液样本测量了游离睾酮。变异系数和方差分析均表明，所有激素的个体间变异性均大于个体内变异性。未确定星期几有影响。然而，发现尽管受试者处于或接近三十岁，但血清激素水平随年龄下降（雌二醇呈弱显著性，雄激素无显著性）。激素之间的合并个体内相关性均处于中度至中高度正相关范围内，而个体间相关性则介于高度正相关（睾酮与双氢睾酮）、中高度正相关（游离睾酮与总睾酮）和轻度负相关（游离睾酮与雌二醇）之间。
