Papasava M, Singer G, Papasava C
Appetite. 1986 Mar;7(1):55-61. doi: 10.1016/s0195-6663(86)80041-1.
Recent findings show that in animals, i.v. self-administration of D-amphetamine, cocaine and phentermine, which act predominantly upon catecholamine (CA) containing neurons, is potentiated following chronic restricted feeding. The objective in this experiment was to determine whether food deprivation would potentiate self-administration of fenfluramine, an anorectic compound which acts predominantly upon serotonin (5HT) containing neurons. When saline and five doses of fenfluramine were made available for i.v. self-administration to naive free-feeding (FF) rats or food-restricted (FR) rats at 80% free-feeding weight, the rate of fenfluramine-reinforced responding did not differ significantly from saline-reinforced responding at any dose or deprivation state. These data suggest that the potentiation of responding which occurs under conditions of chronic restricted feeding is specific to compounds which act predominantly upon CA containing neurons.
最近的研究结果表明，在动物中，静脉注射主要作用于含儿茶酚胺（CA）神经元的右旋苯丙胺、可卡因和苯丁胺，在长期限制进食后其自我给药行为增强。本实验的目的是确定食物剥夺是否会增强芬氟拉明的自我给药行为，芬氟拉明是一种主要作用于含5-羟色胺（5HT）神经元的食欲抑制剂。当将生理盐水和五剂芬氟拉明提供给体重为自由进食体重80%的未接触过药物的自由进食（FF）大鼠或食物限制（FR）大鼠进行静脉自我给药时，在任何剂量或剥夺状态下，芬氟拉明强化反应的速率与生理盐水强化反应的速率均无显著差异。这些数据表明，在长期限制进食条件下出现的反应增强现象，是主要作用于含CA神经元的化合物所特有的。
