通过测定内溶素合成研究沙门氏菌噬菌体P22和L晚期功能的调控。
Regulation of late functions in Salmonella bacteriophages P22 and L studied by assaying endolysin synthesis.
作者信息
Bode W
出版信息
J Virol. 1979 Oct;32(1):1-7. doi: 10.1128/JVI.32.1.1-7.1979.
Abstract
The rate of endolysin synthesis in Salmonella typhimurium cells infected by bacteriophage P22 or L was taken as a measure for the activity of 23 gene product (the positive regulator for the "late" genes of P22 and L). Endolysin in coded for by gene 19. The amber mutations in gene 23 of P22 and L, used in this study, reduced the rate of endolysin synthesis by a factor of ca. 90 for P22 and of ca. 20 for L. In mixed infections with 19- and 23- mutants the 23 gene products of P22 and L ACT As positive regulators for the respective gene 19 in cis and in trans. Cross-specificity of the 23 gene products, i.e., turning on expression of gene 19 on a chromosome of the other species, could not be demonstrated.
摘要
被噬菌体P22或L感染的鼠伤寒沙门氏菌细胞中内溶素的合成速率被用作衡量23基因产物（P22和L“晚期”基因的正调控因子）活性的指标。内溶素由基因19编码。本研究中使用的P22和L的基因23中的琥珀突变，使P22的内溶素合成速率降低了约90倍，使L的内溶素合成速率降低了约20倍。在19和23突变体的混合感染中，P22和L的23基因产物作为顺式和反式中各自基因19的正调控因子。无法证明23基因产物的交叉特异性，即在另一个物种的染色体上开启基因19的表达。
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