• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Dual inhibition of PD-1 and LAG-3: uncovering mechanisms to reverse T cell exhaustion and enhance anti-tumor immunity.

作者信息

Zhou Xiaoxue, Zhou Fangfang, Zhang Long

机构信息

School of Medicine, Hangzhou City University, Hangzhou 310015, China; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310058, China.

School of Medicine, Hangzhou City University, Hangzhou 310015, China; The First Affiliated Hospital, the Institutes of Biology and Medical Sciences, Suzhou Medical College, Soochow University, Suzhou 215031, China.

出版信息

Sci Bull (Beijing). 2025 Mar 15;70(5):624-626. doi: 10.1016/j.scib.2024.11.029. Epub 2024 Nov 22.

DOI:10.1016/j.scib.2024.11.029
PMID:39638663
Abstract
摘要

相似文献

1
Dual inhibition of PD-1 and LAG-3: uncovering mechanisms to reverse T cell exhaustion and enhance anti-tumor immunity.程序性死亡受体1(PD-1)和淋巴细胞激活基因3(LAG-3)的双重抑制:揭示逆转T细胞耗竭和增强抗肿瘤免疫的机制
Sci Bull (Beijing). 2025 Mar 15;70(5):624-626. doi: 10.1016/j.scib.2024.11.029. Epub 2024 Nov 22.
2
LAG-3 and PD-1 synergize on CD8 T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity.LAG-3 和 PD-1 在 CD8 T 细胞上协同作用,导致 T 细胞耗竭,并阻碍自分泌 IFN-γ 依赖的抗肿瘤免疫。
Cell. 2024 Aug 8;187(16):4355-4372.e22. doi: 10.1016/j.cell.2024.07.016.
3
The effect of blocking immune checkpoints LAG-3 and PD-1 on human invariant Natural Killer T cell function.阻断免疫检查点 LAG-3 和 PD-1 对人不变自然杀伤 T 细胞功能的影响。
Sci Rep. 2023 Jun 21;13(1):10082. doi: 10.1038/s41598-023-36468-8.
4
4-1BB-Based CAR T Cells Effectively Reverse Exhaustion and Enhance the Anti-Tumor Immune Response through Autocrine PD-L1 scFv Antibody.基于 4-1BB 的 CAR T 细胞通过自分泌 PD-L1 scFv 抗体有效逆转衰竭并增强抗肿瘤免疫反应。
Int J Mol Sci. 2023 Feb 20;24(4):4197. doi: 10.3390/ijms24044197.
5
Cooperation of PD-1 and LAG-3 in the exhaustion of CD4 and CD8 T cells during bovine leukemia virus infection.牛白血病病毒感染过程中 PD-1 和 LAG-3 在 CD4 和 CD8 T 细胞耗竭中的协同作用。
Vet Res. 2018 Jun 19;49(1):50. doi: 10.1186/s13567-018-0543-9.
6
Monitoring Patient Response to Pembrolizumab With Peripheral Blood Exhaustion Marker Profiles.通过外周血耗竭标志物谱监测患者对帕博利珠单抗的反应。
Front Med (Lausanne). 2019 May 22;6:113. doi: 10.3389/fmed.2019.00113. eCollection 2019.
7
Squamous cell carcinomas escape immune surveillance via inducing chronic activation and exhaustion of CD8+ T Cells co-expressing PD-1 and LAG-3 inhibitory receptors.鳞状细胞癌通过诱导共表达PD-1和LAG-3抑制性受体的CD8+ T细胞的慢性激活和耗竭来逃避免疫监视。
Oncotarget. 2016 Dec 6;7(49):81341-81356. doi: 10.18632/oncotarget.13228.
8
LAG-3 and PD-1+LAG-3 inhibition promote anti-tumor immune responses in human autologous melanoma/T cell co-cultures.淋巴细胞活化基因3(LAG-3)以及程序性死亡受体1(PD-1)加LAG-3抑制可促进人自体黑色素瘤/ T细胞共培养体系中的抗肿瘤免疫反应。
Oncoimmunology. 2020 Mar 12;9(1):1736792. doi: 10.1080/2162402X.2020.1736792. eCollection 2020.
9
Unraveling tumoral heterogeneity and angiogenesis-associated mechanisms of PD-1 and LAG-3 dual inhibition in lung cancers by single-cell RNA sequencing.通过单细胞RNA测序揭示肺癌中PD-1和LAG-3双重抑制的肿瘤异质性和血管生成相关机制
Chin Med J Pulm Crit Care Med. 2025 Mar 14;3(1):41-49. doi: 10.1016/j.pccm.2025.02.004. eCollection 2025 Mar.
10
Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection.活化CD8 T细胞耗竭预示着原发性HIV-1感染的疾病进展。
PLoS Pathog. 2016 Jul 14;12(7):e1005661. doi: 10.1371/journal.ppat.1005661. eCollection 2016 Jul.

引用本文的文献

1
Advances in Tumor Microenvironment and Immunotherapeutic Strategies for Hepatocellular Carcinoma.肝细胞癌的肿瘤微环境与免疫治疗策略进展
Oncol Res. 2025 Aug 28;33(9):2309-2329. doi: 10.32604/or.2025.063719. eCollection 2025.