Wang Jiao, Wang Dandan
Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
Cell Death Discov. 2024 Dec 5;10(1):488. doi: 10.1038/s41420-024-02259-x.
Mitophagy is a process in which impaired or dysfunctional mitochondria are selectively eliminated through the autophagy mechanism to maintain mitochondrial quality control and cellular homeostasis. Based on specific target signals, several mitophagy processes have been identified. Defects in mitophagy are associated with various pathological conditions, including neurodegenerative disorders, cardiovascular diseases, metabolic diseases, and cancer. Mitophagy has been shown to play a critical role in the pathogenesis of gynecological malignancies and the development of drug resistance. In this review, we have summarized and discussed the role and recent advances in understanding the therapeutic potential of mitophagy in the development of gynecological malignancies. Therefore, the valuable insights provided in this review may serve as a basis for further studies that contribute to the development of novel treatment strategies and improved patient outcomes.
线粒体自噬是一个通过自噬机制选择性清除受损或功能失调的线粒体以维持线粒体质量控制和细胞稳态的过程。基于特定的靶信号，已确定了几种线粒体自噬过程。线粒体自噬缺陷与多种病理状况相关，包括神经退行性疾病、心血管疾病、代谢性疾病和癌症。线粒体自噬已被证明在妇科恶性肿瘤的发病机制和耐药性发展中起关键作用。在这篇综述中，我们总结并讨论了线粒体自噬在妇科恶性肿瘤发展中的作用以及在理解其治疗潜力方面的最新进展。因此，本综述提供的有价值见解可能为进一步研究奠定基础，这些研究有助于开发新的治疗策略并改善患者预后。
