Shin Myung Eun, Parra-Bueno Paula, Yasuda Ryohei
Max Planck Florida Institute for Neuroscience, Jupiter, FL, USA.
Nat Neurosci. 2025 Jan;28(1):35-39. doi: 10.1038/s41593-024-01831-z. Epub 2024 Dec 5.
Long-term memory (LTM) consolidation is thought to require the prior establishment of short-term memory (STM). Here we show that optogenetic or genetic CaMKII inhibition impairs STM for an inhibitory avoidance task at 1 h but not LTM at 1 day in mice. Similarly, cortico-amygdala synaptic potentiation was more sensitive to CaMKII inhibition at 1 h than at 1 day after training. Thus, LTM does not require the formation of STM, and CaMKII-dependent plasticity specifically regulates STM for avoidance memory.
长期记忆（LTM）巩固被认为需要先建立短期记忆（STM）。在此我们表明，光遗传学或基因CaMKII抑制会损害小鼠在1小时时对抑制性回避任务的短期记忆，但在1天时不会损害长期记忆。同样，在训练后1小时，皮质-杏仁核突触增强比1天时对CaMKII抑制更敏感。因此，长期记忆不需要短期记忆的形成，并且CaMKII依赖性可塑性特异性调节回避记忆的短期记忆。
