Hené R J, Velthuis P, van de Wiel A, Klepper D, Dorhout Mees E J, Kater L
Arch Intern Med. 1986 Apr;146(4):745-9. doi: 10.1001/archinte.1986.00360160177024.
Granular deposits of IgA are known to occur in the walls of superficial vessels in apparently healthy skin of patients with primary IgA nephropathy, Henoch-Schönlein purpura, or alcoholic liver disease, but the specificity of the finding is still a matter of debate. We investigated the disease specificity of these deposits in the skin of patients with kidney and liver diseases. The sensitivity of the finding for the diagnosis of primary IgA was 75%, the specificity was 88%. The sensitivity for the diagnosis of alcoholic liver disease was 71%, but the specificity was only 60%. The specificity for the diagnosis of Henoch-Schönlein purpura, primary IgA nephropathy, or alcoholic disease (in a group of 1,030 patients with various diseases) was 94%. Immunoelectron-microscopic investigation showed the IgA deposits localized within the endothelial cell and in the subendothelial rim.
已知在原发性IgA肾病、过敏性紫癜或酒精性肝病患者看似健康的皮肤中，浅表血管壁会出现IgA颗粒沉积，但这一发现的特异性仍存在争议。我们研究了这些沉积物在肾脏和肝脏疾病患者皮肤中的疾病特异性。该发现对原发性IgA诊断的敏感性为75%，特异性为88%。对酒精性肝病诊断的敏感性为71%，但特异性仅为60%。对过敏性紫癜、原发性IgA肾病或酒精性疾病（在一组1030例患有各种疾病的患者中）诊断的特异性为94%。免疫电子显微镜检查显示IgA沉积物位于内皮细胞内和内皮下边缘。
